Senior Research Associate, Protein Sciences

About iBio

iBio, Inc. is a preclinical stage biotechnology company leveraging the power of Artificial Intelligence ("AI") for the development of hard-to-drug precision antibodies in the cardiometabolic and obesity space. Our core mission is to harness the potential of AI and machine learning to unveil novel biologics which other scientists have been unable to develop. Through our innovative AI Drug Discovery Platform, we have been able to identify differentiated molecules aimed to address unmet needs by current glucagon-like peptide-1 ("GLP-1") receptor agonists. For more information, visit or follow us on LinkedIn.

The Opportunity

At iBio, we're redefining the future of cardiometabolic therapeutics. Our team pioneers biologics that push the boundaries of science and bring life-changing therapies closer to patients. We're seeking a Senior Research Associate, Protein Sciences to join our dynamic team and play a key role in accelerating the development of novel therapeutics that have the potential to improve patient lives.

This role offers the opportunity to contribute to cutting-edge research, collaborate across cross-functional teams, and drive projects from discovery to preclinical validation. We value scientific curiosity, technical excellence, and the ability to translate complex data into actionable insights.

Location & Work Arrangement: This role is fully onsite at our San Diego office.

What You'll Do:

• Manage the expression and purification of proteins in mammalian cell systems,  supporting multiple teams and molecular biology efforts as needed.
• Develop and employ processes to produce endotoxin-free material.
• Operate and maintain relevant laboratory equipment including incubators, biosafety cabinets, FPLCs, and other related instruments.
• Review and contribute to the creation and revision of SOPs related to expression and purification practices and maintain accurate reporting in an electronic lab notebook system.
• Maintain cleanliness and organization of work areas, ensuring compliance with laboratory safety standards.

Requirements

What We're Looking For:

Scientific Foundation & Journey:

• Bachelor's degree in a relevant scientific discipline and 5+ years of experience in molecular biology and/or protein science operations within the biotech/pharmaceutical industry is required; or,
• Master's degree in a life sciences discipline and 3+ years of experience in molecular biology and/or protein science operations within the biotech/pharmaceutical industry is preferred.

Experimental Mastery & Technical Innovation:

• Knowledge of mammalian cell transfection techniques, especially lipofection, for CHO and HEK293 cells is required.
• Familiarity with chromatography techniques such as protein A, ion exchange, Ni-NTA, and desalting is required.
• Knowledge of endotoxin-removal procedures and methods for maintaining instrumentation to prevent endotoxin contamination.
• Experience with FPLC operation and troubleshooting, particularly using ÄKTA Avant or ÄKTA Pure systems.
• Experience with molecular biology techniques, including cloning (restriction enzyme digestion/ligation, Golden Gate assembly, or Gibson assembly), bacterial transformation and culture, and DNA preparation and characterization.

Scientific Mindset & Agility:

• Strong analytical and problem-solving skills with attention to detail.
• Excellent organizational and time-management abilities.
• Strong verbal and written communication skills.
• Ability to work both independently and collaboratively in a fast-paced environment.

At iBio, your expertise will shape the future of biologics, with opportunities to drive innovation, collaborate with top scientists, and make a real-world impact.

Bring your expertise. Lead with vision. Drive discoveries that change lives.

California Base Salary Range

The expected annual base salary for this position ranges from $77,400.00 to $102,600.00, plus bonus, equity, and comprehensive benefits. The base salary range reflects the target range for this position, but individual pay will be determined by various factors, including the qualifications of the individual applicant for the position, years of relevant experience, job-related skills, relevant education attained, work location, and organizational needs. This range may be modified in the future. A discretionary annual bonus may be available based on individual and Company performance.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identify, national origin, disability, veteran status or other protected classes.

What do we offer?

We provide competitive and comprehensive benefits to our employees. Below are some highlights of our benefits:

• Medical, Dental, and Vision Insurance Options
• Flexible Time Off
• Our company observes seven designated holidays each calendar year. 
• 401(k) with Company Match as described in plan documents.
• Life and Disability Insurance
• Short-term and long-term disability insurance

EEO Statement

iBio is proud of its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability, or any other legally protected status.

iBio is committed to helping individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at iBio, please email for further assistance. Please note that this email address is intended only to request an accommodation as part of the application process. Any other correspondence will not receive a response. 

Notice to Recruiters

Thank you for your interest in iBio and our recruitment opportunities. Recruiting and employment are managed through the Human Resources Department. iBio requires a signed agreement be in place prior the presentation of any candidates. We ask that recruiters and agencies do not contact or solicit employees or managers in an attempt to present candidates. iBio will not be obligated or responsible for any requested fees to candidate resumes that are unsolicited and or submitted to hiring managers without a written agreement between iBio and any recruiters and agencies.