Staff Scientist

5 days ago

Houston, Texas, United States Baylor College of Medicine Full time
Summary

The Department of Genetics at Baylor College of Medicine is seeking a highly motivated individual to join a research laboratory at the Jan and Dan Duncan Neurological Research Institute (NRI). This position focuses on investigating the genetic and molecular mechanisms underlying neurological disorders. The Staff Scientist will support multiple research projects, including studies related to Alzheimer's disease, Parkinson's disease, and MeCP2. The role offers the opportunity to work in a highly collaborative research environment alongside postdoctoral fellows, faculty investigators, and multidisciplinary teams across the NRI to advance ongoing research initiatives.

Job Duties
  • Maintain mouse colonies, including genotyping, breeding cage setup, and conducting mouse behavioral experiments.
  • Conduct mechanistic studies of candidate small-molecule compounds using biochemical, cellular, and molecular biology techniques.
  • Design, optimize, and execute in vitro and in vivo experiments to support target validation, pathway analysis, and mechanistic hypothesis testing.
  • Perform mouse-based preclinical studies, including compound formulation, dosing regimen design, pharmacodynamic (PD) biomarker assessment, and in vivo efficacy evaluation in Alzheimer's disease mouse models.
  • Utilize iPSC-derived cellular models to evaluate compound activity, target engagement, cytotoxicity, and disease relevance, supporting translational interpretation of preclinical data.
  • Support the Principal Investigator and pre- and postdoctoral trainees with ongoing scientific research projects.
  • Maintain recombinant DNA laboratory protocols, including renewals and regulatory submissions.
  • Oversee laboratory equipment, including maintenance coordination and service contracts.
  • Document, analyze, and report experimental results to the Principal Investigator in a timely and accurate manner.
  • Attend departmental seminars, attend weekly lab meetings/journal club meetings.
  • Perform other job-related duties as assigned.
Minimum Qualifications
  • Doctoral Degree. Experience may not be substituted in lieu of degree.
  • Three years of post doctoral research experience.
Department Specific Criteria
  • Experience working with mouse models
  • Experience with small molecule compounds

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.

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