Principal ML Architect
2 weeks ago
Cloud ML Software Architect – Cutting-Edge Biotech + AI Startup
A fast-growing biotech startup is on a mission to reinvent how medicines are discovered. Instead of relying solely on traditional lab testing, this team is building virtual models of human cells—powered by AI—to predict how drugs will work on real patients. Backed by top investors and already partnered with industry leaders like NVIDIA, they've raised over $40M to date and are scaling rapidly.
Location:
South San Francisco (preferred) or Toronto
Stage:
Series A ($30M+) | ~20 employees and growing
Why this role?
The company is expanding from research tools into scalable, production-ready platforms—and they need a
Cloud Software Architect
with proven experience
with
Python Coding & AWS
with experience
supporting heavy-duty ML Workflows / intensive data processing for ML Model Training
to lead the way. You'll be the technical backbone bridging data engineering, bioinformatics, software and machine learning teams, ensuring their software ecosystem is robust, cohesive, and ready to scale.
What you'll do:
- Act as a
hands-on technical leader
: not just writing code, but setting frameworks, architecture, and best practices. - Own
cloud infrastructure
(AWS is core; exposure to GPU compute, Docker & Kubernetes too) - Build bridges across teams, aligning ML, bioinformatics, and software engineering efforts.
- Guide junior engineers and bioinformatics developers while shaping long-term technical strategy.
- Help transition the company from fragmented pipelines to production-grade, external-facing products.
- Influence resourcing and scaling decisions—your input will shape the future of the engineering org.
About you:
- Strong background in
cloud architecture
, especially AWS (EC2, S3, Batch, pipelines). - Hands-on coding experience
in python
plus the seniority to set direction and frameworks. - Proven exp in
complex, data voluminous environments, with a keen interest in Bio/Science
(bio/health/AI/ML is a bonus, but not required). - Familiar with heavy duty
ML workflows
and how compute and data pipelines support them. - Thrives in a
startup setting
—fast-paced, resource-constrained, but high-impact. - Excited by the mission of accelerating drug discovery through AI.E
- Exp supporting computationally-
intensive data processing
and ML model training
Perks & Benefits:
- Competitive compensation
- Unlimited PTO
- Healthcare, 401k, FSA, commuter reimbursement
- H1B transfer and TN visa sponsorship available
- Hybrid: ~3 days/week in office (South SF or Toronto)
If you have a passion for
biotechnology/life sciences
already, have
worked closely with ML Teams and ML Workload,s
and can
code in python
with exp in AWS, please send your resume directly to
-
Principal Architect – Navigation
1 day ago
San Francisco, California, United States FlairX Full timeAbout the jobJob Title: Principal Architect – Navigation (AI/ML) (RL & Simulation focused)Location: San Francisco, CA (Hybrid)Job Type: Full-timeAbout the RoleWe are seeking a highly skilled and visionary Principal Architect – Navigation (AI/ML)for a robotics unicorn based in San Francisco, CA. Backed by over $500 million in funding from top-tier...
-
Principal AI/ML Engineer
1 week ago
San Francisco, California, United States SignalFire Full timeJoin SignalFire's Talent Network for Principal AI/ML Engineer Roles at VC-Backed StartupsAt SignalFire, we partner with top early-stage startups that are shaping the future of technology. Our portfolio spans 200+ innovative companies across AI, cybersecurity, healthtech, fintech, developer tools, and enterprise SaaS.We're looking to connect with exceptional...
-
Staff/Principal ML Engineer
3 days ago
San Francisco, California, United States Transparent Search Group Full timeJob Description: Staff / Principal ML Engineer Predictive Modelling for Alternative AssetsFull-time | Remote (North America) | $240K to $270K + EquityAbout the CompanyA fast-growing fintech startup is revolutionizing the valuation and trading of alternative assets. Their proprietary pricing engine powers real-time valuations, lending decisions, and risk...
-
Principal Solutions Architect
3 days ago
San Francisco, California, United States Elite People Partners Ltd Full timePrincipal Solutions Architect- $300k – $400k – (US – SF Bay Area)We're working with acutting-edge semiconductor innovatordeveloping next-generation AI and compute architectures.This position has already attracted interest fromtop-tier engineers from leading global semiconductor companies, and we're now re-opening the search for aPrincipal Solutions...
-
Principal Platform Architect
2 weeks ago
San Francisco, California, United States PIP Labs Full time $200,000 - $300,000 per yearAbout PIP Labs & StoryPIP Labs is the team behind Story, a purpose-built Layer 1 blockchain designed specifically for intellectual property. With Story, creators can register IP on-chain and set usage terms in seconds, dramatically lowering the barrier of today's complex and antiquated IP legal systems.By making IP programmable, Story transforms intellectual...
-
San Jose, California, United States MediaTek Full time $180,000 - $260,000 per yearJob DescriptionThis is a leadership role on mobile system design for GAI era. The Principal Architect will be responsible for strategic innovations in GAI-oriented mobile system design, and technology development of next-generation AI-enabled products. The architect will work closely with engineering leaders and product managers across geo to investigate the...
-
Data & AI/ML Architect
7 days ago
San Diego, California, United States Aya Healthcare Full time $200,000 - $215,000Join Aya Healthcare, winner of multiple Top Workplace awards We are seeking a highly skilled Data and AI/ML Architect to design and implement scalable data platforms and intelligent systems that power analytics, automation, and decision-making across the organization. This role bridges data engineering, cloud architecture, and machine learning, defining...
-
Principal Engineer
1 week ago
San Francisco, California, United States Strativ Group Full timePrincipal Engineer - AI Infra & InferenceWe are partnered with a Stealth AI Infra startup (backed by a Tier 1 AI Lab and advised by 2 of the world's most prominent ML thought-leaders), who are hiring a Principal SW Engineer (genuine progression to HoE / Chief Engineer).The business already have enterprise customer traction & are backed by Perplexity and the...
-
AI/ML Manager
2 weeks ago
San Francisco, California, United States LeoLabs Full timeWhy LeoLabs? At LeoLabs, we're building the living map of activity in space. Through our proprietary global radar network and AI-enabled analytics platform, we collect millions of measurements daily on more than 241,000 objects in low Earth orbit (LEO). Our radar-powered intelligence protects billions in assets, monitors adversarial behavior, and ensures...
-
Sr ML
1 day ago
San Francisco, California, United States CitiusTech Full timeWho we are: -At CitiusTech, we constantly strive to solve the industry's greatest challenges with technology, creativity, and agility. With over 8,500 healthcare technology professionals worldwide, CitiusTech powers healthcare digital innovation, business transformation, and industry-wide convergence for over 140 organizations through next-generation...