Current jobs related to Senior Scientist, Oligonucleotide Chemist - Petaluma, California - LGC Group
-
Petaluma, California, United States LGC Full timeLGC Axolabs is a business unit of LGC, and a leading provider of CRO / CDMO capability to the therapeutic oligonucleotide discovery and development industry. Centered out of LGC's site in Kulmbach, Germany, Axolabs works closely with its customers to assist the identification and development of lead candidates with a broad suite of bioinformatics, biology,...
-
Senior Scientist, Oligonucleotide Chemist
2 days ago
Petaluma, United States LGC Full timeCompany DescriptionABOUT LGC BIOSEARCH TECHNOLOGIES:With manufacturing sites across the US, UK, Germany and Denmark, LGC Biosearch Technologies has plans to continue growing. We deliver mission critical genomics to our diverse customer base in molecular diagnostics, pharma/biotech and agrigenomics. Our integrated portfolio of products, services and expertise...
-
Senior Scientist, Oligonucleotide Chemist
2 weeks ago
Petaluma, United States LGC Group Full timeCompany Description ABOUT LGC BIOSEARCH TECHNOLOGIES: With manufacturing sites across the US, UK, Germany and Denmark, LGC Biosearch Technologies has plans to continue growing. We deliver mission critical genomics to our diverse customer base in molecular diagnostics, pharma/biotech and agrigenomics. Our integrated portfolio of products, services and...
-
Petaluma, United States LGC Full time5 days ago Be among the first 25 applicants This range is provided by LGC. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more. Base pay range $120,000.00/yr - $145,000.00/yr ABOUT LGC BIOSEARCH TECHNOLOGIES: With manufacturing sites across the US, UK, Germany and Denmark, LGC Biosearch Technologies has...
-
Oligonucleotide Chemist – NPD Tech Lead
1 day ago
Petaluma, United States LGC Full timeA leading life sciences tools company in California is seeking a Senior Scientist, Oligonucleotide Chemist, to innovate in oligonucleotide chemistry. You will develop synthesis and analysis methods, leading projects in a high-growth environment. The ideal candidate has a master's degree and over 10 years of experience in oligonucleotide chemistry with a...
-
Senior Oligonucleotide Chemist
2 weeks ago
Petaluma, United States LGC Group Full timeA leading life sciences tools company is seeking a Senior Scientist specializing in oligonucleotide chemistry in Petaluma, California. The role involves developing and improving synthesis methods and collaborating with multidisciplinary teams to innovate oligonucleotide products. Candidates should have extensive experience in oligonucleotide chemistries and...
-
Senior Scientist I, Analytical Development
3 days ago
Petaluma, United States LGC Full timeCompany DescriptionLGC Axolabs is a business unit of LGC, and a leading provider of CRO / CDMO capability to the therapeutic oligonucleotide discovery and development industry. Centered out of LGC’s site in Kulmbach, Germany, Axolabs works closely with its customers to assist the identification and development of lead candidates with a broad suite of...
-
Scientist II
4 weeks ago
Petaluma, United States Bausch & Lomb Full timeBausch Health is a global company that develops, manufactures, and markets a differentiated product portfolio across multiple high-growth therapeutic areas including Gastroenterology, Generics, Neurology, Ortho Dermatologics, Medical Aesthetics and Dentistry. We are delivering on our commitments as we build an innovative company dedicated to advancing global...
-
Petaluma, United States BioMarin Pharmaceutical Inc. Full timeScientist II, In Vivo, Enzymatic and Metabolic Therapeutic Area 2 days ago Be among the first 25 applicants Who We Are BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Since our founding in 1997, we have applied our scientific...
-
Team Lead Quality Assurance
4 weeks ago
Petaluma, United States LGC, Biosearch Technologies Full timeTeam Lead Quality Assurance Join Axolabs where innovation meets impact in the field of RNA therapeutics. At Axolabs, you will work in an international team that achieves groundbreaking progress in the development of nucleic acid-based medicines from computer-aided drug development through high-throughput screening to large-scale manufacturing. Our...
-
Team Lead Quality Assurance
4 weeks ago
Petaluma, United States LGC, Biosearch Technologies Full timeTeam Lead Quality Assurance Join Axolabs where innovation meets impact in the field of RNA therapeutics. At Axolabs, you will work in an international team that achieves groundbreaking progress in the development of nucleic acid-based medicines from computer-aided drug development through high-throughput screening to large-scale manufacturing. Our...
Senior Scientist, Oligonucleotide Chemist
1 day ago
ABOUT LGC BIOSEARCH TECHNOLOGIES:
With manufacturing sites across the US, UK, Germany and Denmark, LGC Biosearch Technologies has plans to continue growing. We deliver mission critical genomics to our diverse customer base in molecular diagnostics, pharma/biotech and agrigenomics. Our integrated portfolio of products, services and expertise supports our purpose of Science for a Safer World and we have embodied our mission by working with customers to enable research into life-altering treatment for disease and illness worldwide. We are currently seeking candidates who are up for the challenge of operating in a high-growth, purpose-driven organisation.
Job DescriptionJoin LGC as a Senior Scientist, Oligonucleotide Chemist, and help drive innovations in oligonucleotide chemistry. Based in our dynamic Innovation Hub team in Petaluma, CA, you will develop and improve methods for synthesis, deprotection, purification, modification, and analysis. Your work will lead to new oligonucleotide products and ensure their smooth transfer into manufacturing. Work alongside a world-class, multidisciplinary team to achieve outstanding results.
- Ensure compliance with safety regulations and Quality Management policies and processes.
- Act as the Technical Lead in Oligonucleotide NPD and custom/co-creation projects.
- Collaborate with multidisciplinary teams to support both IH and Operations project deliverables.
- Act as the technical oligonucleotide chemistry lead, contributing to the development and delivery of new oligonucleotide-based technologies and applications.
- Independently build, project plan, and complete development projects flawlessly.
- Develop synthesis methods to guarantee the effective application of custom/co-creation/NPD oligonucleotides through both automated synthesizers and manual techniques.
- Optimize methods for oligonucleotide modification and conjugation on-column and post-synthesis.
- Develop and refine purification methods for various modified oligonucleotides and conjugates.
- Perform analytical characterization of oligonucleotides using HPLC, mass spectrometry, and other relevant techniques.
- Troubleshoot synthesis, deprotection, and purification processes to resolve manufacturing issues and improve yield and quality.
- Generate documentation packages to support effective control and transfer into manufacturing.
- Act as the subject matter expert after the tech transfer, providing support with chemistry troubleshooting.
- Maintain accurate records of experiments and results in accordance with laboratory protocols.
- Prepare technical reports and present findings to internal and external collaborators, ensuring effective communication at all business and technical levels.
Minimum qualifications:
- Master's degree in chemistry or a relevant field, or equivalent experience, with a minimum of 10 years of industrial experience in modified oligonucleotide chemistry or demonstrated equivalence.
- Extensive knowledge and practical experience with oligonucleotide chemistries, protocols, and analysis.
- Demonstrated skill in operating automated synthesizers and performing manual synthesis techniques, preferably with systems like MerMade, Dr Oligo, Shasta, K&A, OligoMaker, AKTA.
- Comprehensive understanding of all steps within the synthesis cycle and the impact of changes to methods, cycle times, and reagents.
- Proficiency in predicting oligonucleotide impurity profiles resulting from processing changes.
- Detailed knowledge of deprotection schemes, resulting chemical conformations, and degradation products.
- Familiarity with non-compatible chemistry within oligos and subsequent processing.
- Expertise in oligonucleotide purification chemistries.
- Proficiency in analytical techniques, particularly HPLC and mass spectrometry.
- Demonstrated extensive problem-solving experience.
- Ability to optimize complex chemical processes and adapt to shifting priorities in a fast-paced setting that values accuracy and precision.
- Data-driven decision-making skills.
- Excellent data analysis and interpretation abilities.
- Experience with quality control procedures and GMP regulations.
- Understanding of nucleic acid therapeutics and diagnostics applications.
- Strong organizational skills and attention to detail.
- Excellent written and verbal communication skills in English.
Preferred qualifications:
- Experience in a regulated environment such as ISO 9001.
The typical pay range for this role is:
Minimum: $93,750
Maximum: $156,250
This range represents the low and high end of the anticipated salary range for the California-based position. The actual base salary will depend on several factors such as experience, skills, and location.
About LGC:
LGC is a leading global life sciences tools company, providing critically important components and solutions into high-growth application areas across human healthcare and applied market segments. Our high-quality product portfolio consists of essential tools for genomic analysis and quality assurance applications, valued for their performance, quality, and range.
Our values
- PASSION
- CURIOSITY
- INTEGRITY
- BRILLIANCE
- RESPECT
Equal opportunities
LGC strongly believes that every job applicant and employee should be valued for their individual talents regardless of age, disability, race, color, ethnic or national origin, sex, sexual orientation, gender reassignment, marital or civil partnership, pregnancy or parental leave, religion, or belief. Shortlisting, interviewing, and selection will always be conducted without consideration of gender, sexual orientation, marital status, color, race, nationality, ethnic or national origins, religion or belief, age, or trade union membership.
For more information about LGC, please visit our website
#scienceforasaferworld
