Executive Director, Commercial Data Strategy and Analytics

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a liver disease with high unmet medical need. Madrigal's medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Position Summary

The Executive Director of Commercial Data Strategy and Analytics will be a senior leader responsible for building and scaling Madrigal's global commercial data ecosystem. This role will own the commercial data vision and analytics roadmap in the short and long-term to enable Rezdiffra's trajectory to peak performance, while also laying the foundation for future product launches. The role includes oversight of the commercial analytics team, commercial data management team, and cross-functional insight generation across both U.S. and ex-U.S. markets.

Key Responsibilities

Long-Term Commercial Data Vision & Analytics Strategy

• Define and lead a multi-year commercial data and analytics vision aligned with the long-range brand plan for Rezdiffra and future assets.

• Develop and execute a strategic roadmap to evolve Madrigal's commercial data capabilities, tools, and infrastructure in phases that match business growth and market complexity.

• Identify and prioritize high-value commercial analytics capabilities to support Rezdiffra's growth through launch, acceleration, and maturity.

• Commercial champion for advanced AI and data science capabilities (e.g. predictive analytics, advanced analytics, next-best-action engine)

Commercial Data Strategy & Management

• Own the global commercial data strategy, ensuring scalable integration of specialty pharmacy, hub, claims, CRM, payer, and EMR data to support strategic decision-making.

• Partner closely with IT to ensure commercial data governance is aligned with broader enterprise data architecture, compliance standards, and stewardship protocols.

• Define commercial data quality standards, lineage processes, and best practices for data access, usage, and lifecycle management.

Advanced Analytics & Automation

• Support development of and adoption of enterprise predictive-analytics products and translate their outputs into commercial action plans to drive proactive market insights, early signal detection, and strategic scenario planning.

• Own BI development of key dashboards to automate key analytics across the commercial team

• Champion a culture of data experimentation, agility, and continuous learning within the commercial function.

Global & U.S. Commercial Insights

• Oversee the delivery of integrated insights and analytics across global and U.S. markets, enabling cross-regional consistency while accommodating local market nuances.

• Establish a unified global KPI framework to guide strategic planning and executive performance management

• Oversee commercial analytics team that includes brand analytics leadership and support across all the matrix commercial partners: market access, trade, patient access, sales, and marketing

Specialty Pharmacy, Hub & Brand Data Integration

• Manage end-to-end visibility into the patient experience through the integration of specialty pharmacy and hub data, tracking initiation, drop-off, time-to-therapy, and adherence across geographies.

• Support Rezdiffra brand teams with actionable insights to optimize uptake, address access bottlenecks, and shape future growth strategies.

Team Leadership & Vendor Oversight

• Build and mentor a world-class team of analysts and data experts with commercial and global scope.

• Lead relationships with key analytics vendors, platform providers, and data aggregators (e.g., IQVIA, Symphony, Veeva, Snowflake, hub/SP partners).

• Ensure flexible, scalable analytics resourcing that evolves with the business.

Cross-functional Collaboration & Executive Engagement

• Act as a trusted advisor to Commercial, Medical Affairs, IT, and Executive Leadership teams.

• Communicate data-driven insights with clarity and strategic impact, influencing decisions at the highest levels of the organization.

Qualifications

• Bachelor's degree in a quantitative, technical, or business discipline (e.g., Data Science, Statistics, Engineering, Computer Science, Economics); MBA, MS, or PhD strongly preferred.

• 15+ years of experience in commercial analytics, data strategy, or operations within pharmaceutical or biotech companies, including global and U.S. markets.

• Proven success building long-term analytics strategies to support brand growth from launch through maturity.

• Deep experience with commercial data integration (hub, SP, claims, CRM), master data management (MDM), and enterprise governance frameworks.

• Proficiency in leading advanced analytics projects & stewarding AI/ML development

• Collaborating with IT on enterprise data infrastructure and compliance alignment.

• Exceptional leadership, stakeholder management, and communication skills.

Madrigal's Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.

All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate's qualifications, skills, education, experience, business needs and market demands. The base salary range for this position is $279,000 - $341,000 per year.

All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.   Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws.  We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact   Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.  Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established.  Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site.  Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals' Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal's name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process.   Please also note that any correspondence with regard to employment would come from an authorized email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to  

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