Medical Affairs Operations, Business Project and Operations

Join us as we transform immunology and deliver medicines that help autoimmune patients get their lives back. argenx is preparing for multi-dimensional expansion to reach more patients through a rich pipeline of differentiated assets, led by VYVGART, our first-in-class neonatal Fc receptor blocker approved for the treatment of gMG, and with the potential to treat patients across dozens of severe autoimmune diseases.

We are building a new kind of biotech company, one that maintains its roots as a science-based start-up and pushes our commitment to innovate across all corners of our business. We strive to inspire and grow our company, our partnerships, our science, and our people, because when we do, we deliver more for patients. 

argenx is a biotechnology company committed to developing innovative treatments for diseases with high unmet needs. This role plays a pivotal part in shaping and evolving the US Medical Affairs & Evidence Generation (USMAEG) Operations while stewarding the department's budget planning and tracking. The Business Project and Operations (BPO) manager will lead organizational transformation and cross-functional strategic projects, and will own end-to-end financial management: budget planning, forecasting and tracking; vendor contracting and Statement of Work (SOW) development; and procure-to-pay (P2P) activities—including PO and invoice processing and issue resolution—to ensure timely delivery, compliance, and value for USMAEG initiatives.

Key Responsibilities

Finance & Vendor Operations

• Lead the annual operating plan (AOP) and ongoing re-forecast cycles for the USMAEG portfolio, including launch scenario modeling and alignment with leadership and Finance.

• Establish molecule- and indication-level budget trackers; monitor burn rates, identify variances, and drive mitigation actions with Finance.

• Own monthly/quarterly forecasting and prepare accruals in conjunction with Finance partners.

• Manage end-to-end P2P for USMAEG internal stakeholders: vendor onboarding, requisitions, PO creation/amendment, and invoice processing to policy and cycle-time targets.

• Develop, negotiate, and execute SOWs and change orders with vendors; define scope, deliverables, acceptance criteria, and milestone-based payment schedules in partnership with Legal and Procurement.

• Build dashboards and reports (e.g., Excel, Power BI) that provide real-time visibility into budget consumption, forecast accuracy, and vendor performance.

Strategic Project Management & Transformation

• Design and execute high-impact, cross-functional programs aligned to USMAEG priorities; develop integrated plans, timelines, budgets, and KPIs.

• Lead change management to drive adoption of new processes and systems; facilitate decision-making routines and executive updates.

• Identify and implement process improvements and automation that streamline operations and increase data quality and scalability.

• Coordinate stakeholder and vendor engagement to ensure alignment on objectives, deliverables, risks, and interdependencies.

Cross-Functional Collaboration

• Partner with all functions and teams (HQ & Field) across USMAEG —as well as Finance, Legal, MAEG and Procurement partners—to align plans and enable execution.

• Facilitate budget-to-milestone linkage with medical value narratives for reviews with leadership and governance bodies.

Skills & Competencies

• Strong financial acumen with experience managing multi-million-dollar operating and project budgets and improving forecast accuracy.

• Advanced Excel skills and comfort with data visualization (Power BI or similar).

• Proven strategic project management and planning capability, including KPI design and benefits realization.

• Contracting and vendor management expertise, including SOW structuring, milestone-based payments, and change control.

• Excellent communication, collaboration, and stakeholder/vendor management; ability to influence across levels.

• Detail-oriented with strong organizational skills and proficiency with digital tools/AI to enhance decision-making.

Education & Experience

• Bachelor's degree in Finance, Accounting, Business, Science, or related field; advanced degree or certifications (CPA, MBA, PMP) preferred.

• 3+ years of biopharma experience in medical affairs, strategic operations, or business/financial operations.

• Demonstrated success leading cross-functional initiatives and delivering on-time, on-budget outcomes in a complex, matrixed environment.

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At argenx, all applicants are welcomed in an inclusive environment. They will receive equal consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other applicable legally protected characteristics. argenx is proud to be an equal opportunity employer.

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