Translational NAMs Science

Career CategoryScientificJob DescriptionJoin Amgen's Mission of Serving Patients

At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Translational NAMs Science & Technology Integration Director — Translational Safety & Risk Sciences

What you will do

Let's do this. Let's change the world. In this vital role you will help redefine how translational science informs drug discovery and development through the integration of New Approach Methodologies (NAMs) that enhance human relevance, efficiency, and predicatively. The Director, Translational NAMs Science & Technology Integration within Translational Safety & Risk Sciences (TSRS) will serve as a central catalyst for this transformation—ensuring that state-of-the-art model systems, computational tools, and analytical frameworks are fully leveraged and implemented to enhance translational impact across Amgen's Research organization.

This role is designed to connect the dots: uniting teams within TSRS and building strong partnerships across Research and other key groups within R&D to ensure that emerging in vitro, in silico, and quantitative systems approaches are deployed where they have the greatest translational impact. The successful candidate will combine deep scientific and technical expertise with integrative leadership to accelerate innovation, strengthen translation, and enhance decision-making from early discovery through clinical development

• Scientific and Technological Leadership: Lead the advancement and implementation of state-of-the-art NAMs within TSRS, ensuring Amgen remains at the cutting edge of translational model systems, mechanistic assays, and computational integration.
• Integration Across Research: Build bridges between TSRS wet and dry lab functions and key partners across Research to drive cross-functional learning, coordination, and technology adoption. Establish internal collaborative efforts to apply model systems in next-generation screening and drug development approaches to guide target and therapeutic discovery.
• Technology Advancement: Develop and integrate pioneering 3D tissue models, organoids, micro-physiological systems, computational toxicology, and AI/ML-based modeling to improve translational fidelity and decision quality.
• Data and Systems Integration: Leverage QSP, PK/PD, and mechanistic data (drawing from human genetics, protein modeling, and tissue-level expression data) to build a cohesive framework linking model systems, biomarkers, and clinical endpoints.
• Cross-Functional Collaboration: Lead internal and external collaborations—including with academia, consortia, CROs, and regulatory bodies—to accelerate NAM validation and application.
• Insight Generation: Apply NAMs-driven evidence to translational safety, pharmacology, and biomarker discovery, delivering integrated insights that influence target selection and inform human risk (and mitigation strategies) for development candidates.
• External Representation: Enhance Amgen's leadership in NAMs science by contributing to global consortia, regulatory initiatives, and high impact scientific publications that advance the field.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a self starter with these qualifications.

Basic Qualifications:

Doctorate degree and 4 years of relevant scientific experience

Or

Master's degree and 7 years of relevant scientific experience

Or

Bachelor's degree and 9 years of relevant scientific experience

Preferred Qualifications:

• Ph.D. in Cell Biology, Molecular Biology, Pharmacology, Systems Biology, Biomedical Engineering, or a related field with 10 years of experience spanning drug discovery, translational research, or safety sciences.
• Recognized expertise in New Approach Methodologies (NAMs), including advanced in vitro models, quantitative systems pharmacology, or AI/ML-driven translational modeling.
• Demonstrated scientific leadership in developing, implementing, and integrating new technologies across the research continuum.
• Consistent track record of influencing portfolio decisions through data-driven, mechanistic insight.
• Experience mentoring and developing scientific staff and leading cross-functional or matrix teams.
• Strong external visibility through publications, consortium leadership, regulatory engagement, or scientific presentations.
• Exceptional communication and collaboration skills, with the ability to align diverse stakeholders and translate complex science into strategic impact.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.

The expected annual salary range for this role in San Francisco is $240,284 - $280,634. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models, including remote and hybrid work arrangements, where possible

Apply now and make a lasting impact with the Amgen team.

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.

Salary Range

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