Senior Scientist

1 day ago

New York, United States Mount Sinai Health System Full-time

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Description

The Senior Scientist will drive computational analysis of high-dimensional datasets, partnering closely with a well-integrated computational-experimental team to generate biological insights from complex genomic data. The ideal candidate has deep expertise in single-cell transcriptomics and epigenomics, experience handling large-scale datasets, and strong quantitative and programming skills. Experience in machine learning and AI approaches is highly desirable.

ResponsibilitiesLead analysis of single-cell RNA-seq and multiome datasets (joint RNA/ATAC profiling)Perform integrative analysis across modalities, including bulk RNA-seq, ATAC-seq, and DNA methylation datasetsDevelop processing pipelines for novel single cell multiomic technologiesApply statistical modeling and machine learning methods to identify cellular states, regulatory programs, and epigenetic signaturesDesign and implement integrative multi-omic analyses across cohorts and experimental systemsPresent findings internally and contribute to publications and grant applicationsStay current with emerging single-cell and AI-driven genomic analysis methodologiesPerforms other related duties.
Qualifications Ph.
D in sciences or related field (Computational Biology, Bioinformatics, Genomics, Statistics, Computer Science, or related field) Minimum five years of experience with scientific investigation. Must have demonstrated outstanding achievement in a field of research Must have contributed to a number of peer-reviewed publications, inventions or the like, at least some of which have had a major impact on advancing the field or discipline. Prior experience successfully securing external grant funding is highly desirable.Highly Preferred

Experience:
Strong experience analyzing bulk and single-cell RNA-seq and epigenomic dataProficiency in R, including common single-cell analysis frameworksExperience working with large-scale genomic datasets and high-performance computing environmentsStrong statistical background and data visualization skillsExperience analyzing DNA methylation data (e.g., array-based or sequencing-based approaches)Experience analyzing long-read RNA sequencing datasetsDemonstrated use of machine learning/AI methods for genomic data integration or predictionFamiliarity with cloud-based workflows and reproducible pipeline developmentTrack record of publications in peer-reviewed journals
Employer Description

Strength through Unity and Inclusion

The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.

At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history.

About the Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes mor

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