Senior Scientist/Principal Investigator-BioAnalytical Services

Scientist/ Senior Scientist/ Principal Scientist, method Developer, Large Molecules Quantitation by LC-MS/MS, Bioanalytical ServicesLocation: Exton, PA Full timeResponsibilities:Mainly responsible for developing bioanalytical quantitation methods for large molecules in biological matrices using LC-MS/MS platform, including triple quadrupole and high-resolution MS instrument.Directly working with method development team head to design the experimental activities to address the bioanalytical challenges of the method, conduct the experiments, summarize the method development results, discussion with the team head of the experimental results and present the results internally and to sponsors.Simultaneously handle multiple method development projects or method qualification/method validation as required. Coordinate study activities with supervisor and internal team to ensure efficiency and quality of the projects within the timeline.Coordinate with internal team, like PI and PMs, to deliver the established methods to internal team for method validation and sample analysis within the expected timeline. Provide technical support and troubleshooting in cases the method performance does not meet the expectation.Maintain the proper level of regulatory compliance for each study, helping to address QC/QA audit findings.Keep track of industry trending on the quantitation of large molecules using LC-MS platform. Assess, evaluate and implement new technologies or instruments in the GLP labs to improve the analysis efficiency or data quality.Set-up, utilize, and maintain complex instrumentation Follow safety precautions.Responsible for all technical related discussion and method development.Routinely provide technical training to internal team. Serve as mentor for junior scientists in the team. Help with training and/or mentoring of junior scientific staff. Ensure that GLP regulations and SOPs are followed in all bioanalytical service activities.Maintain schedule of projects and timelines, communicate project timelines, status, and data to Principal Investigator effectively addressing any issues that may arise.Ability to work on multiple projects at the same time.Maintain tools, computer programs, and SOPs required for studies. Research literature and external sources and identify new techniques and procedures that strengthen Frontage’s capabilities.Work with support teams including sample management, lab support, metrology, QC, TW, PM & QA, BD as well as other PI’s and management to deliver quality results on time for clients.Education and Requirements:Prior working experience working large molecules, such as peptides, Oligos, mAbs, ADCs or sugar, lipids, etc;Prior working experience in triple quadrupole MS and High-Resolution MS instrument; Experience with Sciex QTOF instrument and/or Thermo Orbitrap Exploris 240 HRMS is a plus.Prior experience developing and validating bio-analytical methods for the quantitation of small molecules and large molecules in biological matrices using LC-MS/MS platform in a GLP lab.Experience using Sciex Analyst software, OS software, and Thermo Chromeleon and Watson LIMS is a plus.Quick learning capability and self-motivation.Flexible in the working schedule to meet the project timeline.Proven ability to successfully work in a team environment. Excellent oral and written communication skills. Understanding of experimental design and planning, data collection and summarize the experimental results and presentation skills, and familiar with common data analysis software.Ph.D. in Analytical Chemistry, Biochemistry, Pharmacology or related scientific discipline with 1-2+ years direct experience, OR Master’s degree in same disciplines with 2-4+ years direct experience in large molecules quantitation field using LC-MS/MS platform, OR Bachelor’s degree in same discipline with 5+ years direct experience in large molecules quantitation field using LC-MS/MS platform.Salary and Benefits:Frontage Laboratories offers a competitive compensation and generous benefits package including health and dental insurance, a 401(k) plan, health insurance, short and long-term disability insurance, life insurance etc.Frontage Laboratories Inc. is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, among other things, or status as a qualified individual with disability.