Biomarker Scientist, Cancer Gene Therapy
1 week ago
Biomarker Scientist, Cancer Gene TherapyYou will lead the planning and execution of biomarker strategy and drive biomarker assay development for preclinical and clinical oncology studies using gene therapy modality. In this role, you will collaborate with cross-functional teams and external partners to drive clinical biomarker innovation for cancer gene therapy programs. This is an ideal position for a highly motivated individual who has strong wet-lab and data analysis skills, and thrives in a cross-disciplinary and collaborative environment.Primary ResponsibilitiesEstablish translatable biomarkers for preclinical and clinical development, including biomarkers for patient selection, drug response monitoring, pharmacodynamics and mechanism of action.Design and validate biomarker assays, developing SOPs for robust and reproducible biomarker quantification using patient-derived specimens. Contribute to biomarker strategy in clinical trials.Work closely with the biospecimen team to optimize, standardize and document pre-analytical biospecimen handling and processing conditions to support the transition of biomarker assays into clinical trials.Oversee and manage relationships with CROs and vendors for outsourced clinical biomarker assay development, validation, and regulatory compliance.Analyze biomarker data to derive insights into patient response, pharmacodynamics, and mechanisms of action.Collaborate with regulatory teams to ensure biomarker strategies align with clinical trial and regulatory submission requirements.Required Skills & Qualifications PhD and/or MD with 3+ years of industry experience in oncology disease or cell/gene therapy (CGT).Excellent understanding of drug development and regulatory processes.Extensive hands-on experience developing biomarker assay protocols and analyzing patient specimens using techniques such as IHC/IF, ISH, ELISA and ELISPOT.Experience leading biomarker assay outsourcing with external vendors/CROs.Excellent written and communication skills.Thrives in a fast-paced, high-growth environment with a track record of delivering resultson time and within budgetProven ability to work independently and collaboratively in a team environment.At Pattern Bio, we design biological circuits at the intersection of synthetic biology and AI for cell-specific targeting of cancer tissue. By integrating data-driven design into every stepfrom DNA constructs to AAV-based delivery systemswe are building precise, rationally engineered, curative therapies. Our cohesive and driven team in South San Francisco is dedicated to curing cancer and saving lives.PI14ad4e70b5b4-30511-38354299
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Senior Scientist, In Vitro Pharmacology
1 week ago
San Francisco, United States Altos Labs Full timeOur MissionOur mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life. Our ValueOur Single Altos Value: Everyone Owns Achieving Our Inspiring Mission.Diversity at AltosWe believe that diverse perspectives are foundational to scientific innovation and...
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San Carlos, California, United States BeOne Medicines Full timeBeOne continues to grow at a rapid pace with challenging and exciting opportunities for experienced professionals. When considering candidates, we look for scientific and business professionals who are highly motivated, collaborative, and most importantly, share our passionate interest in fighting cancer.General DescriptionWe are seeking an accomplished and...
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Scientist II, Clinical Bioinformatics
1 week ago
San Francisco, California, United States Revolution Medicines Full timeRevolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment...
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ML Engineer, Discovery Applications
3 weeks ago
San Francisco, United States Mithrl Full timeThis range is provided by Mithrl. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more. Base pay range $150,000.00/yr - $240,000.00/yr ABOUT MITHRL We imagine a world where new medicines reach patients in months, not years, and where scientific breakthroughs happen at the speed of thought. Mithrl is building...
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Field Application Scientist
4 weeks ago
San Francisco, United States Pave Talent Full timeA biotechnology firm is seeking a Technical Sales Specialist / Field Application Scientist to drive sales in cellular immunotherapy and gene editing. This role entails managing strategic accounts and collaborating with sales and technical teams. The ideal candidate will have a background in life sciences and sales experience along with excellent...
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Summer Intern
3 weeks ago
San Diego, United States Insmed Full timeSummer Intern - Gene Therapy Research At Insmed, every moment and every patient counts and so does every person who joins in. As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases, you'll be part of a community that prioritizes the human experience, celebrates curiosity, and values every person's...
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Head of Clinical Biomarkers, West Coast Hub
4 weeks ago
San Francisco, United States Biogen Full timeHead Of Clinical Biomarkers, West Coast HubBiogen's West Coast Hub, based in South San Francisco, is specifically focused on transforming the lives of patients with severe immune-mediated diseases by developing novel targeted therapies with outsized clinical impact, faster. To accomplish this, we are seeking top talent to join us on our journey.About This...
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ML Engineer, Discovery Applications
4 days ago
San Francisco, CA, United States Mithrl Full timeABOUT MITHRL We imagine a world where new medicines reach patients in months, not years, and where scientific breakthroughs happen at the speed of thought. Mithrl is building the world's first commercially available AI Co-Scientist. It is a discovery engine that transforms messy biological data into insights in minutes. Scientists ask questions in natural...
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ML Engineer, Discovery Applications
7 days ago
San Francisco, CA, United States Mithrl Full timeABOUT MITHRL We imagine a world where new medicines reach patients in months, not years, and where scientific breakthroughs happen at the speed of thought. Mithrl is building the world's first commercially available AI Co-Scientist. It is a discovery engine that transforms messy biological data into insights in minutes. Scientists ask questions in natural...
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ML Engineer, Discovery Applications
1 week ago
San Francisco, CA, United States Mithrl Full timeABOUT MITHRL We imagine a world where new medicines reach patients in months, not years, and where scientific breakthroughs happen at the speed of thought. Mithrl is building the world's first commercially available AI Co-Scientist. It is a discovery engine that transforms messy biological data into insights in minutes. Scientists ask questions in natural...
