Staff Scientist
6 days ago
Job Description Job Title: Staff Scientist - T-Cell Biology Division: Medicine Work Arrangement: Onsite only Location: Houston, TX Salary Range: $65,000 - $75,000 FLSA Status: Exempt Work Schedule: Monday – Friday, 8 – 5 Summary We are seeking a highly motivated Staff Scientist to join our team investigating the mechanisms of T-cell dysfunction and immune evasion following allogeneic hematopoietic cell transplantation (allo-HCT). Our laboratory integrates expertise in epigenetics, chromatin regulation, and immunology to understand how altered gene regulatory programs drive T-cell exhaustion, impaired graft-versus-leukemia (GVL) responses, and post-transplant relapse in acute myeloid leukemia. The Staff Scientist will play a central role in developing and leading mechanistic projects, applying chromatin profiling, CRISPR functional genomics, and single-cell multi-omics to dissect the regulatory networks underlying T-cell dysfunction and identify therapeutic strategies to restore immune surveillance. What We Offer A highly collaborative environment bridging epigenetics, immunology, and cancer therapy. Access to state-of-the-art single-cell platforms, CRISPR libraries, and mouse models for allo-HCT and leukemia. Opportunities for professional growth, including mentorship in grant writing. Job Duties Lead mechanistic studies of donor T-cell dysfunction post-allo-HCT, with a focus on chromatin regulators, histone modifications, and transcriptional/epigenetic drivers of exhaustion. Apply single-cell transcriptomics, epigenomics (ATAC-seq, CUT&Tag), and CITE-seq to map dysfunctional T-cell states in murine models and patient samples. Use CRISPR/Cas9 screening and perturbation approaches to identify novel regulators of T-cell persistence, effector function, and exhaustion. Collaborate with wet-lab and computational teams to integrate multi-omics datasets with clinical outcomes. Mentor trainees and contribute to team science efforts, including multi-PI grants and translational collaborations. Contribute to manuscripts, conference presentations, and grant applications. Perform other job related duties as assigned. Minimum Qualifications Doctoral Degree. Experience may not be substituted in lieu of degree. Three years of post doctoral research experience. Preferred Qualifications in Immunology, Epigenetics, Computational Biology, or related fields. Strong publication record with first-author papers in relevant areas. Demonstrated expertise in epigenetic/chromatin biology and its role in immune regulation or cancer biology. Hands-on experience with T-cell biology, single-cell approaches, or CRISPR screening. Strong data analysis skills and ability to work collaboratively across experimental and computational projects. Experience studying T-cell exhaustion, GVHD/GVL biology, or allo-HCT models. Knowledge of checkpoint pathways, metabolic regulation, or cytokine signaling in T cells. Background in integrating clinical datasets with mechanistic studies. Familiarity with drug discovery approaches (, PROTACs, epigenetic inhibitors) that may reverse T-cell dysfunction. Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer. SN Requisition ID: 23544
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Staff Scientist
2 weeks ago
Houston, United States Baylor College of Medicine Full timeJob Description Job Title: Staff Scientist - Epigenomics Division: Advanced Technology Cores Work Arrangement: Onsite only Location: Houston, TX Salary Range: $65,000 - $89,824 FLSA Status: Exempt Work Schedule: Monday – Friday, 8 – 5 Summary The Genomic and RNA Profiling (GARP) Core is an Advanced Technology Core Facility for the College...
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Staff Scientist
5 days ago
Houston, United States Baylor College of Medicine Full timeJob Description Job Title: Staff Scientist - Medicinal Chemistry Division: Pathology Work Arrangement: Onsite only Location: Houston, TX Salary Range: $65,000 FLSA Status: Exempt Work Schedule: Monday – Friday, 8 – 5 Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer. SN Requisition...
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Staff Scientist
4 days ago
Houston, Texas, United States Baylor College of Medicine Full time $100,000 - $200,000 per yearSummaryThe Center for Drug Discovery ) is a strategic research center established at Baylor College of Medicine (BCM) in Houston, Texas. The mission of the Center for Drug Discovery is to establish novel discovery technologies that enable rapid and cost-effective drug discovery within the academic community. We are seeking highly skilled and motivated...
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Staff Scientist
1 day ago
Houston, United States Baylor College of Medicine Full timeJob Description Job Title: Staff Scientist - DNA and Biospecimen Division: Advanced Technology Cores Work Arrangement: Onsite only Location: Houston, TX Salary Range: Hiring up to $78,000 FLSA Status: Exempt Work Schedule: Monday – Friday, 8 – 5 Summary The Population Sciences Biorepository (PSB) is an Advanced Technology Core for the...
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Staff Research Scientist
3 weeks ago
Houston, United States TPC Group Full timePOSITION SUMMARY TPC Group is seeking a Senior Research Scientist with significant experience in Organic Chemistry to contribute to the design, synthesis, characterization, and application development of novel organic molecules and intermediates that create differentiated performance in fuel and lubricant additives, adhesives, sealants, coatings, polymer...
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Staff Scientist
2 days ago
Houston, United States Baylor College of Medicine Full timeSummaryWe are seeking a highly motivated Staff Scientist to join our team investigating the mechanisms of T-cell dysfunction and immune evasion following allogeneic hematopoietic cell transplantation (allo-HCT). Our laboratory integrates expertise in epigenetics, chromatin regulation, and immunology to understand how altered gene regulatory programs drive...
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Staff Applied Scientist
18 hours ago
Houston, TX, United States Relativity Full timePosting Type Hyrbid Job Overview At Relativity, we're building a world-class Applied Science team to push the boundaries of intelligent systems in the legal domain. We're looking for a Staff Applied Scientist to join our team. Agentic AI-systems that perceive, think, and act-is not a far-off vision for us. It's already embedded in how Relativity aiR makes...
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Staff Data Scientist, Life Sciences AI
3 weeks ago
Houston, United States IMO Health Full timeJoin to apply for the Staff Data Scientist, Life Sciences AI role at IMO HealthAt IMO Health, a core team of software developers, data scientists, and domain experts combine computer science, healthcare, and life sciences expertise to help professionals access high-quality health information quickly and easily. We need a Staff Data Scientist, Life Sciences...
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Staff Scientist I/II
2 weeks ago
Houston, United States Seeds Renewables Full timeA leading environmental consulting firm in Houston is seeking a Staff Scientist for their Permitting and Compliance team. This role involves assisting on multimedia projects, performing calculations, and ensuring project objectives are met. Candidates should have a B.S. degree in a relevant field, with 0-3 years of regulatory experience preferred....
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Staff Data Scientist: Life Sciences AI
2 weeks ago
Houston, United States Imohealth Full timeA healthcare data innovation company based in Houston is seeking a Staff Data Scientist to design and develop AI-driven tools that facilitate advanced evidence synthesis. The ideal candidate will have a PhD or equivalent experience, in-depth knowledge of statistical modeling, and expertise in engineering AI solutions for healthcare applications. The role...
