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Associate Research Scientist

2 months ago


Seattle, United States Synectics Inc Full time
Job DescriptionJob Description

Responsibilities:

  • The Sr. RA/Assoc. Scientist will join the Gene Delivery and Editing Process Development (GDEPD) organization supporting process development for next generation gene delivery and editing teams.

  • Will be an integral part of establishing a platform process to produce lipid nanoparticles (LNPs), which are critical to generating our groundbreaking cell therapies.

  • Will join the LNP Platform Development team working on initiatives intended to drive next-generation LNP platform development focused on gene editing capabilities.

  • Will participate in a thorough and rapid process development campaign to establish new LNP capabilities within.

  • This role will focus on producing robust processes for LNP production, while also gaining familiarity with analytical assays for LNP characterization.

  • The unique opportunity to learn about multiple other critical gene editing raw materials and modalities.

  • Execute and troubleshoot process development experiments which will support platform development of LNPs production.

  • Assist in the design of experiments and interpretation of data relating to LNP production and purification.

  • Support characterization efforts of LNPs.

  • Collaborate closely and assist mRNA platform teams.

  • Manage the flow of samples and data and perform analyses.

  • Optimize workflows for assessing new modes of production and purification.

  • Support research-to-development transition endeavors, including early-stage/pipeline molecular assessment activities.

  • Actively participate and support lab maintenance and continuous improvement initiatives.

  • Maintain accurate and detailed laboratory notebook and documentation.

  • Summarize and present data in group meetings and contribute to group discussions and team strategy.

  • Author technical reports and study memos.

Qualifications:

  • STEM degree with 2+ years of relevant industry experience; title/compensation will ultimately be commensurate with education, experience, and skillset

  • An in-depth knowledge of LNPs, with at least 2 years of demonstrated experience with LNPs

  • Capability to identify LNP critical quality attributes and how process parameters may directly impact these attributes

  • Experience designing scalable LNP process unit operations (tangential flow filtration, distilled filtration, production of LNPs)

  • Experience with JMP for DoE design and analyses

  • Independently motivated with ability to work in teams

  • Ability to communicate clearly and concisely through oral presentation and technical writing.

  • Ability to leverage literature, internal and external resources to solve problems

  • Desire to identify and advance the cutting edge

  • Possess a growth mindset and the ability to thrive in a fast-paced, highly collaborative environment

Preferred Qualifications:

  • Demonstrated experience with TFF and sterile filtration of biological molecules

  • Degree in biological or chemical engineering, biochemistry, or bio-related field

  • Experience with LNP characterization techniques (HPLC, DLS, MALs, NTA, Ribogreen etc.)

  • Experience with handling of nucleic acids

  • Experience downstream purification of biological molecules (AKTA, chromatography, TFF, viral filtration, etc.)

  • Experience with development of continuous processes and implementation process-analytical technologies (PATs)

  • Experience with microfluidic technologies

  • Experience in the development of other gene delivery or editing materials (e.g. adeno-, retro-, lenti-, RNPs, Cas, mRNA, etc.)