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Associate Research Scientist
2 months ago
Responsibilities:
The Sr. RA/Assoc. Scientist will join the Gene Delivery and Editing Process Development (GDEPD) organization supporting process development for next generation gene delivery and editing teams.
Will be an integral part of establishing a platform process to produce lipid nanoparticles (LNPs), which are critical to generating our groundbreaking cell therapies.
Will join the LNP Platform Development team working on initiatives intended to drive next-generation LNP platform development focused on gene editing capabilities.
Will participate in a thorough and rapid process development campaign to establish new LNP capabilities within.
This role will focus on producing robust processes for LNP production, while also gaining familiarity with analytical assays for LNP characterization.
The unique opportunity to learn about multiple other critical gene editing raw materials and modalities.
Execute and troubleshoot process development experiments which will support platform development of LNPs production.
Assist in the design of experiments and interpretation of data relating to LNP production and purification.
Support characterization efforts of LNPs.
Collaborate closely and assist mRNA platform teams.
Manage the flow of samples and data and perform analyses.
Optimize workflows for assessing new modes of production and purification.
Support research-to-development transition endeavors, including early-stage/pipeline molecular assessment activities.
Actively participate and support lab maintenance and continuous improvement initiatives.
Maintain accurate and detailed laboratory notebook and documentation.
Summarize and present data in group meetings and contribute to group discussions and team strategy.
Author technical reports and study memos.
Qualifications:
STEM degree with 2+ years of relevant industry experience; title/compensation will ultimately be commensurate with education, experience, and skillset
An in-depth knowledge of LNPs, with at least 2 years of demonstrated experience with LNPs
Capability to identify LNP critical quality attributes and how process parameters may directly impact these attributes
Experience designing scalable LNP process unit operations (tangential flow filtration, distilled filtration, production of LNPs)
Experience with JMP for DoE design and analyses
Independently motivated with ability to work in teams
Ability to communicate clearly and concisely through oral presentation and technical writing.
Ability to leverage literature, internal and external resources to solve problems
Desire to identify and advance the cutting edge
Possess a growth mindset and the ability to thrive in a fast-paced, highly collaborative environment
Preferred Qualifications:
Demonstrated experience with TFF and sterile filtration of biological molecules
Degree in biological or chemical engineering, biochemistry, or bio-related field
Experience with LNP characterization techniques (HPLC, DLS, MALs, NTA, Ribogreen etc.)
Experience with handling of nucleic acids
Experience downstream purification of biological molecules (AKTA, chromatography, TFF, viral filtration, etc.)
Experience with development of continuous processes and implementation process-analytical technologies (PATs)
Experience with microfluidic technologies
Experience in the development of other gene delivery or editing materials (e.g. adeno-, retro-, lenti-, RNPs, Cas, mRNA, etc.)