Chemist

3 weeks ago

Worcester, United States Synectics Inc Full time
Job DescriptionJob Description

Description:

  • Discovery Biotherapeutics and Genetic Medicine (BGM) at is seeking a highly motivated scientist to join its Protein Sciences Analytical Team.

  • This position offers a unique opportunity to contribute to various Discovery Research Therapeutic Areas (TAs) and Projects by providing analytical and functional characterization of biologics and biopharmaceutical products, such as complex protein antigens, monoclonal antibodies, multi-specifics, and other antibody-like biologics.

  • As part of our team, your work will drive the discovery and development of groundbreaking treatments.

  • Conduct mass spectrometry analyses for comprehensive characterization of biologics and biotherapeutics, including intact, reduced, subunit, and peptide mapping approaches.

  • Perform regular analytical assessments of biologics utilizing methods such as Size Exclusion Chromatography (SEC), Reverse Phase Liquid Chromatography (RPLC), Capillary Electrophoresis (CE), and automation technologies.

  • Ensure the optimal functioning of laboratory equipment through routine maintenance and effective troubleshooting of experimental challenges.

  • Evaluate, document, and succinctly report experimental data, formulate well-supported conclusions, and design subsequent experiments informed by multidisciplinary insights.

  • Document laboratory activities in Electronic Laboratory Notebooks (ELN) in accordance with best practices for good documentation.

  • Work closely with other scientists and departments to ensure alignment and progress on project goals.

  • Contribute to team discussions, share valuable insights, and present experimental findings and progress updates to colleagues and stakeholders.

Qualifications:

  • Bachelor's or Master's degree in Chemistry/Biochemistry with 3+ years of relevant experience.

  • Demonstrated hands-on expertise with various mass spectrometry platforms, including Orbitrap and Q-ToF, along with proficiency in MS workflows for protein characterization and the use of MS software for analyzing both routine and complex datasets.

  • Solid analytical proficiency in a range of chromatographic and capillary electrophoresis techniques.

  • Familiarity with biophysical and structural methods, such as Dynamic Light Scattering (DLS), Differential Scanning Fluorimetry (DSF), Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS), and X-ray crystallography, is a plus.

  • Experience in working with biologics, monoclonal antibodies, and/or protein therapeutics is a plus.

  • Goal-oriented team player with exceptional verbal and written communication skills, a strong positive attitude, and the ability to thrive in a fast-paced, multidisciplinary environment.

  • HPLC required

Benefits:

Healthcare Insurance: Synectics offers eligible employees and their dependents healthcare coverage through BlueCross BlueShield of Illinois. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics. Premiums are subsidized by Synectics.

Dental Insurance: Synectics offers eligible employees and their dependents a dental plan through MetLife. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics.

Vision Insurance: Synectics offers eligible employees vision insurance through VSP. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics.401(k) Plan: The Synectics Inc. Investment Savings Retirement Plan. Synectics offers all employees who are 21 years of age or older the opportunity to invest in the 401(k) Plan on the first enrollment date that is at least 30 days after employment begins. Enrollment dates are each January 1st, April 1st, July 1st, and October 1st.

Technical Certification Bonus: Synectics is pleased to award its employees a bonus of up to $500 for an approved professional certification. In determining the bonus amount, Synectics will consider the cost of the test(s) for any certification relating to your current position, achieved during your employment with us. Only one Certification Bonus per calendar year may be awarded per employee. Only current, active employees will be eligible to receive this bonus. It will be awarded 90 days after the Synectics office has received documentation confirming the successful completion of the certification.

Synectics is an equal opportunity employer.

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