Postdoctoral Research Fellow

7 days ago

Baltimore, Maryland, United States Case Western Reserve University Full time
Postdoctoral Research Fellow Opportunity

We are seeking a highly motivated and experienced Postdoctoral Research Fellow to join our team at the Institute for Transformative Molecular Medicine. The successful candidate will have a strong background in biochemistry, animal handling, and physiological assessment, with a focus on asthma models in mice.

Key Responsibilities:
  • Coordinate laboratory research activities and follow approved animal protocol and standard workflow to induce asthma-like state in mice.
  • Perform mouse surgery to install ventilator system, and measure airway reaction to bronchoconstrictor and bronchorelaxant drugs to quantify lung dysfunction.
  • Isolate bronchoalveolar lavage fluid for assessment of immune cell infiltration into lung, and isolate mouse tissues to perform histology staining for lung integrity and biochemical assays to measure protein levels and S-nitroso-protein levels.
  • Utilize samples from human primary airway epithelial and smooth muscle cells to validate findings in mice, and maintain ongoing records of work and analysis performed.
  • Work closely with the principal investigator and with supervising investigator, keeping them informed of progress and difficulties, and evaluate adequacy of techniques and study and test new procedures and analyze data.
  • Supervise students and technicians, specifically training in techniques and overseeing their use, and organize overall research work and recent progress in summary presentations for oral/visual presentation to local research group and to the off-site members of the PPG.
Requirements:
  • Ph.D. degree in a natural science-relevant field required.
  • 3 to 5 years of related research experience required, with rodent handling experience for at least 1 year strongly recommended.
  • Experience with rodent asthma models, mouse surgery, and flexiVent or similar ventilator system is a strong plus.
Working Conditions:

The successful candidate will work in a general laboratory environment, with extensive work with laboratory mice, and may have exposure to hazards, particularly including dust mite allergens used for allergic asthma modeling in mice.

We offer a dynamic and collaborative research environment, with opportunities for professional growth and development. If you are a motivated and experienced researcher looking for a new challenge, we encourage you to apply.

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