Research Scientist
5 days ago
The Pharmacoanalytical Shared Resource (PhASR) at The Ohio State University is seeking a highly skilled Researcher 4 to support various clinical trials and drug development projects. This is a term position with the potential to extend beyond the one year term.
Key Responsibilities:- Apply in-depth knowledge of analytical chemistry and bioanalytical methodologies to drive efficient project design and implementation.
- Develop and validate analytical assays using LC-MS/MS, ELISA, or other appropriate analytical platforms according to FDA guidelines.
- Manage projects, supervise individual contributors in assay development and validation, and guide/lead less experienced researchers.
- Plan, develop, and manage analytical methods to quantitatively characterize mechanisms of absorption, distribution, metabolism, and excretion of novel drugs or drug candidates.
- Troubleshoot and maintain LC-MS/MS systems.
- Prepare biological specimens by protein precipitation, phospholipid removal, liquid-liquid and solid phase extraction for ELISA and LC-MS/MS analyses, and for analysis by other methods as appropriate.
- Lead and train less experienced researchers on the preparation of biological tissues for experimental studies.
- Lead and participate in the development of study-related goals.
- Develop and test experimental designs, sampling techniques, and analytical methods to make recommendations for implementation.
- Research published studies and incorporate new knowledge and information into PhASR projects.
- Maintain accurate and detailed research records, including a laboratory notebook, method, and project-related documentation.
- Consult and collaborate with principal investigators to guide bioanalytical and pharmacology aspects of their research.
- Perform FDA Bioanalytical method validation on newly developed and existing methods.
- Work with the technical director to ensure adherence to strict quality control standards by serving as a quality control reviewer.
- Establish quality control standards for developed analytical assays in adherence with the FDA guidance.
- Develop SOPs and maintain laboratory equipment by performing routine maintenance and scheduling contracted maintenance services when necessary.
- Generate invoices, track expenses, and produce quotes for analytical services.
- Assist with day-to-day operations, including receipt of samples and packages while completing appropriate documentation.
- Follow established laboratory safety procedures to ensure compliance with OSHA regulations and local, state, and federal regulations.
- Prepare method and project reports, research papers, and manuscripts for publication and presentation at national conferences and workshops.
- Serve as a resource for less experienced scientists.
- Train and supervise other staff on developed protocols, equipment, and laboratory procedures.
- Perform additional duties as assigned.
- PhD in chemistry, biochemistry, pharmacology, or science-related field.
- 7-10 years of experience with sample preparation and analysis using ELISA, LC-MS/MS, or flow cytometry.
- Hands-on experience with the development of LC-MS/MS or ELISA analytical methods.
- Clinical sample analysis and/or FDA bioanalytical method validation would be preferred, but not required.
- 8-12 years of relevant experience preferred.
The Ohio State University is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to age, ancestry, color, disability, ethnicity, gender identity or expression, genetic information, HIV/AIDS status, military status, national origin, race, religion, sex, gender, sexual orientation, pregnancy, protected veteran status, or any other basis under the law.
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