Senior Purification Scientist

2 weeks ago

Rahway, New Jersey, United States Merck Full time
Job Description

At Merck, we are committed to advancing healthcare and well-being through innovative research and development. Our Research Laboratories is a hub for discovery and development of world-changing therapeutics, and we are seeking a highly motivated Senior Purification Scientist to join our team.

Responsibilities
  • Utilize a wide range of established techniques, including HPLC, SFC, and Mass Spectrometry, to support our Discovery Chemistry portfolio.
  • Setup, implement, and maintain lab-deployed analytical and preparative instruments, specifically Waters or Agilent mass-directed preparative systems.
  • Develop novel purification capabilities and implement automation and data integration to optimize end-to-end purification workflows.
  • Interact closely with chemists and other purification groups across our Research and Development Division to share best practices and develop new capabilities.
  • Collaborate with IT professionals to integrate instrumentation with LIMS systems.
  • Program, integrate, and troubleshoot liquid handling, UPLC, LC/MS equipment from vendors including Waters, Agilent, Tecan.
  • Knowledge of informatics such as Spotfire, VB, Pipeline pilot, and basic Windows programs.
Qualifications
  • Bachelor's degree in Chemistry, Engineering, Computer Science, Life Sciences, or equivalent, and 5 years of technical expertise in purification science, knowledge of analytical chemistry, strong organizational and communication skills, an ability to adapt to a fast-paced team environment, and experience with state-of-the-art purification technologies and automation systems.
  • OR - Master's degree and 3 years of experience.
Required Experience
  • Demonstrate working knowledge of analytical chemistry and ability to use a wide range of state-of-art preparative instruments to deliver high-quality, high-efficiency purifications.
  • Proficient in data analysis using instrument software, such as Masslynx, ChemStation, or Virscidian, and able to use automation technology to streamline the end-to-end synthesis-to-assay workflow.
  • Ability to think strategically, highly organized with strong attention to detail.
  • Apply scientific knowledge to assist with scientific decision-making and application of appropriate technologies.
  • Excellent communication and interpersonal skills and the ability to work in a fast-paced team.
  • Strong instrument troubleshooting and routing maintenance abilities.
  • Must be able to prioritize resources to deliver required level of output for highest priority projects.
  • Self-starter with ability to work independently and multi-tasking.
Preferred
  • Experience working in pharmaceutical or biotech company.
  • Experience working in a synthetic and/or analytical chemistry laboratory.
  • Experience with Waters or Agilent analytical and preparative instruments, liquid handling systems - (HighResBio, Beckman, Tecan).
  • Proficient in data analysis using Masslynx, ChemStation, Virscidian, and other data analysis software.
  • Experience with implementing and integrating large-scale and small-scale automation with LIMS, e.g., Empower, GBG, Cellario, Momentum.
  • SQL/Oracle programming.
  • Microsoft programming languages (VB, C++, Python, or equivalent).

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