Senior Purification Scientist
2 weeks ago
At Merck, we are committed to advancing healthcare and well-being through innovative research and development. Our Research Laboratories is a hub for discovery and development of world-changing therapeutics, and we are seeking a highly motivated Senior Purification Scientist to join our team.
Responsibilities- Utilize a wide range of established techniques, including HPLC, SFC, and Mass Spectrometry, to support our Discovery Chemistry portfolio.
- Setup, implement, and maintain lab-deployed analytical and preparative instruments, specifically Waters or Agilent mass-directed preparative systems.
- Develop novel purification capabilities and implement automation and data integration to optimize end-to-end purification workflows.
- Interact closely with chemists and other purification groups across our Research and Development Division to share best practices and develop new capabilities.
- Collaborate with IT professionals to integrate instrumentation with LIMS systems.
- Program, integrate, and troubleshoot liquid handling, UPLC, LC/MS equipment from vendors including Waters, Agilent, Tecan.
- Knowledge of informatics such as Spotfire, VB, Pipeline pilot, and basic Windows programs.
- Bachelor's degree in Chemistry, Engineering, Computer Science, Life Sciences, or equivalent, and 5 years of technical expertise in purification science, knowledge of analytical chemistry, strong organizational and communication skills, an ability to adapt to a fast-paced team environment, and experience with state-of-the-art purification technologies and automation systems.
- OR - Master's degree and 3 years of experience.
- Demonstrate working knowledge of analytical chemistry and ability to use a wide range of state-of-art preparative instruments to deliver high-quality, high-efficiency purifications.
- Proficient in data analysis using instrument software, such as Masslynx, ChemStation, or Virscidian, and able to use automation technology to streamline the end-to-end synthesis-to-assay workflow.
- Ability to think strategically, highly organized with strong attention to detail.
- Apply scientific knowledge to assist with scientific decision-making and application of appropriate technologies.
- Excellent communication and interpersonal skills and the ability to work in a fast-paced team.
- Strong instrument troubleshooting and routing maintenance abilities.
- Must be able to prioritize resources to deliver required level of output for highest priority projects.
- Self-starter with ability to work independently and multi-tasking.
- Experience working in pharmaceutical or biotech company.
- Experience working in a synthetic and/or analytical chemistry laboratory.
- Experience with Waters or Agilent analytical and preparative instruments, liquid handling systems - (HighResBio, Beckman, Tecan).
- Proficient in data analysis using Masslynx, ChemStation, Virscidian, and other data analysis software.
- Experience with implementing and integrating large-scale and small-scale automation with LIMS, e.g., Empower, GBG, Cellario, Momentum.
- SQL/Oracle programming.
- Microsoft programming languages (VB, C++, Python, or equivalent).
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