Senior Scientist

12 hours ago

Waltham, Massachusetts, United States BostonGene Full time
About BostonGene

BostonGene is a pioneering biotech company that develops cutting-edge software for advanced patient analysis and personalized therapy decision-making in cancer treatment. Our innovative solution integrates cancer research and clinical data to empower clinicians in tailoring optimal treatment strategies for individual patients.

Job Overview

We are seeking a highly skilled Senior or Principal Scientist to lead the day-to-day operation of our R&D NGS platform. This individual will oversee a team that develops, validates, implements, and continuously improves NGS assays at BostonGene. The successful candidate will manage the NGS R&D test portfolio, including various DNA and RNA sequencing tests from tissue, cells, and plasma, ensuring the highest standards of quality, efficiency, and innovation.

Key Responsibilities
  • NGS Assay Development & Quality Control:
    • Develop and standardize NGS test methods for measuring patient samples, including tissue and liquid biopsy-based DNA and RNA-based tests.
    • Establish and maintain rigorous quality control and quality assurance processes.
    • Monitor and evaluate performance metrics to ensure the highest quality of sequencing data.
    • Troubleshoot and resolve technical issues across NGS teams to minimize downtime and maintain operational continuity.
  • Technology and Innovation:
    • Stay abreast of the latest advancements in NGS technological and genomic research.
    • Work with R&D leadership to evaluate and implement new technologies and methods to keep the company at the cutting edge of genomic testing.
    • Maintain a process of continuous improvement and analytical validation of testing platforms.
  • Cross-Functional Collaboration:
    • Work closely with internal clinical operations, bioinformatics, regulatory, and other R&D platform teams to deploy NGS tests for commercial and academic collaboration projects.
    • Collaborate with external partners, vendors, and regulatory bodies as needed.
    • Work with project management and alliance teams to assess project feasibility and define project scope.
  • Leadership and Strategy:
    • Execute strategic plans for NGS operations to support the company's NGS product portfolio, support clinical trials, collaborations, and internal R&D assay development.
    • Lead, mentor, and manage a high-performing team of scientists, laboratory technicians, and bioinformaticians.
    • Foster a culture of innovation, collaboration, and excellence within the NGS teams in the BG laboratory.
  • Budget and Resource Management:
    • Develop and manage budgets for NGS assay development and assay improvements, ensuring cost-effective use of resources.
    • Oversee procurement and maintenance of laboratory equipment and supplies.
    • Identify and implement cost-saving measures without compromising quality.
Requirements
  • Ph.D. or Master's degree in Molecular Biology, Genetics, Genomics, or a related field.
  • 5-10 years of experience in commercial NGS test development, validation, and tech transfer into a CLIA/CAP/GCLP environment.
  • Experience writing detailed SOPs and successfully implementing them in a complex multi-omic workflow.
  • Deep knowledge of existing and emerging NGS technologies, proficiency in practical genomic data analysis, and up-to-date with the current genomic literature.
  • Deep expertise in troubleshooting NGS protocols from nucleic acid extraction to sequencing.
  • Working knowledge of bioinformatics approaches and experience collaborating with computational scientists and bioinformaticians.
  • Excellent leadership, communication, and interpersonal skills.
  • Track record of training and mentoring junior scientists and research associates.
  • Demonstrated ability to function in a fast-paced, dynamic environment and manage multiple priorities simultaneously.
  • Experience with regulatory compliance in clinical genomics is a plus.

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