Protein Purification Engineer

6 days ago


South San Francisco, California, United States AbbVie Full time

About the Job

We are seeking an experienced Protein Purification Engineer to join our Biologics CMC Development team at AbbVie in the Bay Area. This team has a long history of biologics development and works collaboratively through all phases of CMC development.

Key Responsibilities

  • Develop, optimize, and scale up purification processes.
  • Work with contract labs and carry out viral clearance studies.
  • Support transfer processes to GMP manufacturing sites for clinical material production.
  • Write technical reports and author/present technical presentations.

Requirements

  • Bachelor's degree in Chemical Engineering, Biochemistry, Chemistry, or other sciences with 5 years of experience, or MS degree with 2 years of experience.
  • At least 5 years of CMC protein purification development experience with standard bioprocess unit operations such as chromatography separations and filtration operations.
  • Extensive experience with AKTA chromatographic instruments and Unicorn method writing.
  • Excellent attention to detail and ability to keep detailed written records.
  • Demonstrated ability to design, execute, and interpret critical experiments to answer scientific questions.
  • Strong planning, time management, and analytical skills.

Preferred Qualifications

  • Hands-on experience with monoclonal antibody or antibody-like molecule purification at GMP, pilot, and/or laboratory scale.
  • Unit operation development experience including cell culture harvest, affinity chromatography, polishing chromatography, virus filtration, and ultrafiltration/diafiltration.
  • Understanding of analytical techniques such as HPLC, LAL, and ELISA.

Estimated Salary Range: $120,000 - $150,000 per year.

Benefits

  • Comprehensive package of benefits including paid time off, medical/dental/vision insurance, and 401(k) to eligible employees.
  • Short-term incentive programs.


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