Protein Purification Engineer
6 days ago
About the Job
We are seeking an experienced Protein Purification Engineer to join our Biologics CMC Development team at AbbVie in the Bay Area. This team has a long history of biologics development and works collaboratively through all phases of CMC development.
Key Responsibilities
- Develop, optimize, and scale up purification processes.
- Work with contract labs and carry out viral clearance studies.
- Support transfer processes to GMP manufacturing sites for clinical material production.
- Write technical reports and author/present technical presentations.
Requirements
- Bachelor's degree in Chemical Engineering, Biochemistry, Chemistry, or other sciences with 5 years of experience, or MS degree with 2 years of experience.
- At least 5 years of CMC protein purification development experience with standard bioprocess unit operations such as chromatography separations and filtration operations.
- Extensive experience with AKTA chromatographic instruments and Unicorn method writing.
- Excellent attention to detail and ability to keep detailed written records.
- Demonstrated ability to design, execute, and interpret critical experiments to answer scientific questions.
- Strong planning, time management, and analytical skills.
Preferred Qualifications
- Hands-on experience with monoclonal antibody or antibody-like molecule purification at GMP, pilot, and/or laboratory scale.
- Unit operation development experience including cell culture harvest, affinity chromatography, polishing chromatography, virus filtration, and ultrafiltration/diafiltration.
- Understanding of analytical techniques such as HPLC, LAL, and ELISA.
Estimated Salary Range: $120,000 - $150,000 per year.
Benefits
- Comprehensive package of benefits including paid time off, medical/dental/vision insurance, and 401(k) to eligible employees.
- Short-term incentive programs.
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