Senior Scientist, PK/PD Modeling Expert

4 weeks ago

Chicago, Illinois, United States AbbVie Full time
Job Description

AbbVie is seeking a highly skilled Senior Scientist to join our Quantitative, Translational and ADME Sciences (QTAS) group. The ideal candidate will have expertise in mechanistic and translational modeling, with a strong background in PK/PD modeling and project support.

Key Responsibilities:

  • Develop and implement innovative, quantitative analyses and strategies for translational modeling across Discovery and Development projects
  • Liaise with Discovery biology, pharmacology, toxicology, biomarker, QTAS and clinical scientists to generate data and knowledge supporting the generation and implementation of translational models
  • Establish and maintain effective collaborations with key peer and team stakeholders within QTAS, Discovery and Clinical to facilitate knowledge and data integration for target prioritization, biomarker selection, candidate selection, guidance in (pre)clinical study design, human dose prediction and calculation of therapeutic index
  • Effectively communicate on strategies related to drug metabolism and pharmacokinetics (DMPK) and translational modeling and simulation
  • Maintain awareness of emerging literature and science in computational approaches and applications

Qualifications:

  • Bachelors (B.S.), Masters (M.S.), or Doctorate (Ph.D.) in chemical, mechanical, or biomedical engineering; applied mathematics; quantitative pharmaceutical sciences or a related field, with typically B.S.), 8-11 (M.S.), or 0-5 (Ph.D.) years of pharmaceutical industry experience
  • Hands-on experience with relevant modeling software and programming languages including MATLAB/SimBiology, R, Python, WinNonLin/Phoenix, etc. is required
  • Understanding of small or large molecule drug modalities and relevant analytical methods for measuring drug and biomarker levels in preclinical and clinical study samples is highly desired
  • Experience in working with AI/ML frameworks, in relevant applications such as QSAR and predictive biomarker/endpoint models to interface with mechanistic PK/PD models is highly desired
  • Passion for data analysis, solving technical problems and applying new technologies to further scientific goals and answer key scientific questions enabling informed decision-making
  • Publication record demonstrating PK/PD or systems modeling examples is highly desired
  • Highly-motivated, self-driven and results-oriented person with excellent communication and presentation skills, capable of both leading and being lead
  • High degree of flexibility in adapting to different projects and personalities as well as excellent networking and relationship-building skills (both internal and external) required
  • Must have strong communication skills and the ability to effectively communicate with both internal and external stakeholders, and to audiences of diverse backgrounds
  • Prior experience in an experimental in vitro or in vivo biology field is desired
  • Interest in developing skills to support projects as a QTAS project representative in future is highly desired

Additional Information:

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVie's policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

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