About XBiotech USA, Inc.

XBiotech USA, Inc. is a premier drug Research & Development organization based in Austin, Texas. Our facility encompasses all essential operations including discovery, research and development, drug testing, product formulation, and clinical-regulatory affairs.

As a fully integrated biopharmaceutical company, XBiotech manages all aspects of drug development under one roof, from preclinical models to clinical trial execution, and from discovery to manufacturing. Our focus is on creating antibody therapeutics that address significant medical needs in inflammatory diseases and cancer.

Position Overview:

XBiotech is in search of a highly driven and innovative Scientist to join our Rodent Pharmacology-Toxicology team. This team is responsible for designing and developing animal models for cancer, inflammation, and infectious diseases to evaluate novel drugs from our discovery pipeline. Additionally, the team conducts in vivo nonclinical safety studies that vary from acute to chronic durations, adhering to Good Laboratory Practices (GLP) regulations.

Key Responsibilities:

• Design and execute cutting-edge research in in vivo pharmacology and toxicology to support XBiotech's research pipelines in Inflammatory, Oncology, and Infectious diseases.
• Conduct in vivo rodent studies to assess pharmacokinetics and pharmacodynamics of antibody therapeutics.
• Plan and perform toxicology and safety pharmacology studies using rodent models.
• Design and implement in vivo studies to evaluate the efficacy of novel therapeutics targeting inflammation, oncology, and infectious diseases.
• Handle various responsibilities including animal handling, administering test substances, health monitoring, clinical observations, and data collection.
• Perform necropsies and collect organs and tissues for histopathological analysis.
• Ensure compliance with IACUC guidelines and maintain adherence to IACUC and AAALAC regulations.
• Execute ex vivo techniques such as flow cytometry, western blotting, and ELISA as needed.
• Maintain meticulous laboratory records and documentation.
• Draft Standard Operating Procedures and adhere to Good Laboratory Practices.
• Analyze and interpret scientific data, effectively communicating findings to project teams and regulatory bodies.
• Work independently and tackle problems without direct supervision.

Qualifications:

• Ph.D. in pharmacology, toxicology, or a related scientific discipline.
• A minimum of 5 years of experience in nonclinical development, toxicology, or veterinary medicine within the pharmaceutical or biotechnology sectors.
• Proficient in in vivo and ex vivo techniques.
• Able to work independently or collaboratively in a team environment.
• Flexibility to work weekend shifts and off-hours as required.
• Familiarity with regulatory guidance documents and GLP regulations.
• Strong communication skills and the ability to address scientific and regulatory inquiries effectively.
• Detail-oriented with a capacity for critical and innovative thinking.

Work Environment:

• Fast-paced atmosphere requiring multitasking abilities.
• Ability to manage projects with minimal supervision.

Employee Value Proposition:

• Contribute to the development of groundbreaking therapies that have the potential to impact millions globally.
• Engage with cutting-edge technology and streamlined manufacturing processes.
• Collaborate with a distinguished team of professionals experienced in scientific services.
• Be part of a pioneering company in the commercialization of antibody products.
• Enjoy a casual and supportive workplace culture with opportunities for growth.