Senior Scientist II, Pathology Expert

4 weeks ago


Waltham, Massachusetts, United States AbbVie Full time
Job Description

We are seeking a highly motivated individual to work within the Precision Medicine Pathology Group to develop and implement tissue-based assays to support drug development in oncology and other therapeutic areas.

The Senior Scientist will drive the design, implementation, and analysis of diagnostic and translational tissue-based biomarkers and participate in target discovery and validation projects.

This role will accomplish this by conducting histopathological evaluation as well as computer-based image analysis of IHC and other tissue-based assays, as well as by providing technical/scientific leadership in these areas.

Key Responsibilities:

  • Design, validate, and implement histochemical, IHC, and IF staining using Leica Autostainer XL, Ventana Discovery ULTRA, and Leica BOND RX platform.
  • Perform routine histological procedures including tissue accessioning, gross-dissection, tissue processing, embedding, sectioning, staining, and image capture of frozen and FFPE tissues.
  • Perform image capture (whole slide scanning), data entry, and organization.
  • Perform image analysis using HALO and Visiopharm technologies.
  • Generate data and present findings to relevant project teams in departmental and cross-functional meetings.
  • Lead and maintain external vendor collaborations and relationships.
  • Train staff in image analysis, quantification, and spacial biology techniques.
  • Evaluate and bring in new and innovative image analysis and spacial biology tools and techniques.

Qualifications:

  • Bachelor's Degree in Science-related field with 15+ years of related work; Master's Degree in Science with 10+ years of related work; PhD in Science or related field with 4+ years of related work experience.
  • Strong familiarity with the principles of tissue microscopic anatomy/histology.
  • Experience working in collaboration with trained pathologists.
  • Hands-on experience with development of immunohistochemistry (IHC) and other tissue-based assays including immunofluorescence (IF) multiplexing and in situ hybridization (ISH) preferred.
  • Expertise in quantitative image analysis software and its application to IHC and other tissue-based staining modalities.
  • Excellent verbal communication skills are required including the demonstrated ability to effectively and clearly summarize results for presentation and report generation.

About AbbVie:

AbbVie is a global biopharmaceutical company that discovers and develops innovative medicines and solutions to solve serious health issues. We are committed to operating with integrity, driving innovation, transforming lives, serving our community, and embracing diversity and inclusion.



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