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Radiology Technologist

2 months ago

Boston, Massachusetts, United States Mass General Brigham Full time
Job Title: PET Radiochemist

Mass General Brigham is seeking a highly skilled PET Radiochemist to join our team in Boston, Massachusetts.

Job Summary:

The PET Radiochemist will be responsible for the routine production and quality control of novel and literature radiotracers for clinical and pre-clinical use at BWH cyclotron and associated radiochemistry facilities. This position will act as an assistant to the Director of Radiochemistry Research & Development in the implementation and optimization of radiochemical syntheses and analytical methods to support candidate novel and literature molecular imaging biomarkers for clinical and preclinical use.

Key Responsibilities:
  • Collaborate with the Director of Radiochemistry Research & Development to select potential compounds of interest and develop a budget and schedule to bring a compound of interest into use for pre-clinical and/or human studies.
  • Work with BICOR management and PIs to define, budget, and introduce new equipment for project-specific production and quality control testing needs while meeting all applicable regulatory requirements.
  • Translate published quality control methods from literature or industry-recognized guidelines to the BICOR quality lab using existing equipment.
  • Develop and properly complete appropriate SOPs and batch records for compounds of interest as a PET GMP operator.
  • Define adequate levels of chemicals and disposables for new compounds and set up receiving, quarantining and qualification of chemistry reagents and materials in accordance with cGMP for new compounds.
Requirements:
  • One of the following: BS in Chemistry with a minimum of 6+ years of direct experience in PET IND radiosynthesis meeting the requirements of USP and/or 21 CFR 212, or MS in Chemistry with a minimum of 3+ years of experience in organic synthesis of compounds, radiometal chemistry, analytical chemistry, or other field applicable to chemical synthesis or quality control.
  • Experience in quality control methodology for quantification and identity of chemical moieties in analytical samples, including experience with High Performance Liquid Chromatography, Gas Chromatography, Thin Layer Chromatography, Liquid Chromatography/mass spectrometry, and chromogenic endotoxin testing.
  • Experience with the production of C-11, N-13, and F-18 PET radiopharmaceuticals and automated synthesis units for F-18 and C-11 radiopharmaceuticals.
  • Strong competence in PET radiopharmaceutical quality control methodology, including High Performance Liquid Chromatography, Thin Layer Chromatography, Liquid Chromatography/mass spectrometry, Gas Chromatography, and chromogenic endotoxin testing.
  • Experience with radioactive detectors, including dose calibrators, solid state detectors, and sodium iodide well counters.
  • Experience with cGMP laboratory procedures and utilizing USP chapters to support work performed within the GMP manufacturing environment.
  • Fluency with desktop computing and the Microsoft 365 suite.
What We Offer:

Mass General Brigham provides a welcoming environment to employees, patients, and families of diverse cultures, ethnic backgrounds, ages, lifestyles, and physical abilities. Our hospitals are consistently ranked as top hospitals by U.S. World News Report.

We offer a competitive salary and benefits package, including medical, dental, and vision benefits, life insurance, and employee assistance programs.

Join our team and be part of something greater. Learn from others and be inspired. Work hard to solve for unknowns. Chase solutions. Be a part of something greater.