Associate Director, Pharmacogenetics Expert
4 days ago
We are seeking a highly skilled and experienced individual to join our team as an Associate Director of Pharmacogenetics within the Translational Genetics and Phenomics team.
About the RoleThe successful candidate will have extensive experience in genetics and/or pharmacogenetics and should have experience of working in different therapeutic areas. They should have accrued experience across the different components necessary to deliver scientific projects in pharmacogenetics, including the incorporation of genetics in clinical trials, human biological sample management, scientific ideation, oversight of data analysis with reporting of scientific findings, and educating and upskilling colleagues in genetics.
Key Responsibilities- Lead scientific efforts to evaluate and prosecute opportunities to understand the role of genetics in influencing response to drugs in clinical studies.
- Collaborate with stakeholders across Human Genetics and Genomics (HGG), Precision Medicine, Clinical Development, and therapy areas to design and undertake pharmacogenetics experiments that are aligned to clinical development program needs to support decision-making.
- Identify and enable opportunities to use genetic data from clinical studies to address further scientific questions.
- Work with agility to adapt to changing priorities and timelines, including the provision of pharmacogenetics support to clinical teams.
- Stay up to date with the latest scientific advancements in pharmacogenetics and drive the development and implementation of innovative and evolving pharmacogenetic scientific approaches (e.g., polygenic risk scores) to support and impact the pipeline.
- Stay up to date with relevant regulations and guidelines concerning the collection and storage of genetic samples and analysis of genetics data from international clinical studies.
- Support and optimize processes required for pharmacogenetics, including, for example, oversight of sample vendors and internal guidance documents.
- Identify opportunities and lead external collaborations to advance the science of pharmacogenetics.
- Foster a culture of partnership, innovation, and continuous learning within the team.
- PhD in a scientific discipline with ideally 5+ years of relevant research experience.
- Track record of innovation and scientific excellence in genetics with experience of pharmacogenetics, preferably in an industry setting.
- Demonstrated evidence of effective delivery of complex projects.
- Experience of working in and leading multidisciplinary teams to answer complex scientific questions.
- Exposure to a range of different types of human genetic and genomic data, including genotyping and sequencing data and their integration with other genomic data (e.g., proteomics).
- Experience of working in and leading scientific collaborations with external partners.
- Experience of processes required in pharmacogenetics, including incorporating genetics into clinical studies, management of genetic samples and data, guiding or undertaking data analyses.
- Excellent communication and presentation skills to effectively convey complex concepts in genetics to different audiences.
- Experience of educating and upskilling others in genetics and/or pharmacogenetics.
- Experience of working in a regulated environment with understanding of the drug development process.
- Thirst for continual professional self-development, with a focus on scientific excellence.
- Experience of working in a range of disease areas.
- Experience of return of individual participant genetic results.
- Strong project management skills with ability to prioritize and a focus on delivering results.
- Initiative to identify and implement creative solutions.
- Familiarity with biomarker development requirements and associated regulatory processes.
We are an equal opportunities employer and welcome applications from all qualified candidates. If you are interested in this role, please submit your application, including your CV and a cover letter, to us by the closing date of 11th October 2024.
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