Senior Staff Engineer

4 weeks ago

Boston, Massachusetts, United States Takeda Pharmaceuticals Full time

About the Role:

Takeda Pharmaceuticals is seeking a highly skilled Senior Staff Engineer to join our Process Engineering & Technology Group. As a Senior Staff Engineer – Process Modeling, you will be responsible for leading and contributing to the design, development, optimization, and scale-up of manufacturing processes for synthetic molecule drug substances using process modeling and simulation principles.

Key Responsibilities:

  • Lead and contribute to the design, development, optimization, and scale-up of manufacturing processes for synthetic molecule drug substances using process modeling and simulation principles.
  • Utilize advanced process modeling tools and digital twin functionalities, implementing model-based design of experiments for process characterization and risk assessment.
  • Collaborate with cross-functional and external partners to develop and deploy digital twins of unit operations.
  • Partner with Automation, Manufacturing, Process Engineers, and PAT experts to develop modeling and simulation (M&S) solutions that can be deployed across the global organization for in-silico process design, development, and optimization.
  • Recommend, justify and implement in silico tools and an "in-silico first" approach to process development.

Requirements:

  • Bachelor's degree in Chemical Engineering or a related pharmaceutical science with 11+ years of relevant industry experience.
  • Master's degree in Chemical Engineering or a related pharmaceutical science with 9+ years of relevant industry experience.
  • Ph.D. or postdoctoral fellowship in Chemical Engineering or a related pharmaceutical science with 3+ years of relevant industry experience.
  • Strong knowledge and understanding of chemical reaction engineering and catalysis, with proven ability to demonstrate skills in these fields.
  • Strong knowledge and understanding of transport phenomena and thermodynamics.
  • Extended experience with commercially available reaction kinetic modeling software such as Ansys, ReactionLab, Dynochem, and gPROMS.
  • Extended experience with commercially available software for computational fluid dynamics (CFD) modeling such as Ansys, Star CCM+, MStar CFD.
  • Proficient in communicating and data collection from systems such as sensors, controllers, and industrial systems.
  • Experience with Matlab, Python, R, SQL, and good coding practices.

Preferred Qualifications:

  • Experience with common statistical methods, basic data science principles, and AI/ML methodologies.
  • Hands-on experience in wet lab process development.
  • Experience in multivariate analysis and Principal Component Analysis (PCA).
  • Understanding of synthetic molecule process development activities.
  • Understanding of current Good Manufacturing Practices (cGMP).

Knowledge and Skills:

  • Analytical and Problem Solving Skills - Able to troubleshoot critical issues or problems, and determine causes and possible solutions.
  • Teamwork Ability to work well in highly cross functional team environment and across global line functions.
  • Communication Skills -Able to expresses one's self clearly and concisely within team; documents issues and/or concerns concisely with colleagues; adjust communication style as appropriate for the audience; timely and effectively communicates issues to supervisor; technical writing skills to support authorship of internal technical documents.
  • Organization – Exercises good time management and prioritization skills and is able to successfully manage multiple tasks simultaneously.
  • Knowledge Sharing - Ability to capture organizational knowledge; improve solutions, processes, and deliverables through use of information; improve information capital by contributing experience, theories, deliverables, and models for others to use.
  • Resource Management - Ability to manage one's time within individual, departmental, and corporate goals and timelines; management of internal and external resources (vendors).
  • External Involvement – Demonstrated involvement in professional community evidenced by presentation of scientific posters or lectures at professional conferences or events.
  • Technical - Subject matter expertise and knowledge of applicable process modeling and simulation tools.

Travel Requirements:

May require approximately 5-10% travel.

About Takeda:

Takeda Pharmaceuticals is a patient-focused company that is transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. We are committed to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

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