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Biological Associate Scientist
2 months ago
BioPhase Solutions is dedicated to connecting exceptional talent with leading organizations in Southern California's scientific sector. We are currently seeking an Associate Scientist, Biology to contribute to a prominent biopharmaceutical organization in the Greater Los Angeles area.
Compensation: $35-50/hour based on experience.
Key Responsibilities:- Actively engage as a member of the viral vector upstream team, responsible for designing, planning, and executing laboratory experiments to facilitate process development, characterization, and enhancements.
- Conduct hands-on work in adherent cell stack factories or suspension culture, including cell culture expansion, viral vector production, and scaling up processes for implementation in GMP clinical production environments.
- Draft and review technical documentation to ensure accuracy and compliance.
- Collaborate and influence a cross-functional development team to advance production initiatives.
- Develop manufacturing processes for viral vector products while identifying process improvements and efficiencies.
- Analyze processes and monitor performance trends to ensure optimal operations.
- Design and implement process development studies to gain a comprehensive understanding of operational and performance parameters.
- Proficient knowledge of suspension or adherent cell culture formats, scale-up techniques, and engineering principles (e.g., growth rates, specific consumption/production rates, bioreactor design).
- Hands-on expertise in cell line engineering, attribute selection, and cell sorting (FACS), with experience in isolating high-yield cell lines.
- Extensive experience in laboratory cell culture operations, including maintenance and growth of cells in both static and suspension modes, with a focus on developing high productivity vector cell lines.
- Demonstrated excellence in viral vector or cell culture process development, technology transfer, scale translation, and statistical design of experiments (DOE).
- Ability to build, operate, and troubleshoot bench-top and pilot-scale bioreactors, along with compiling and analyzing results.
- Experience with regulatory filing preparations for domestic and international markets is preferred.
- Understanding of GMP manufacturing standards and practices.
- Minimum of 7 years of experience with a BS degree in Chemical/Biochemical Engineering, Biochemistry, Biology, or a related scientific field.
- At least 5 years of experience with an MS degree in Chemical/Biochemical Engineering, Biochemistry, Biology, or a related scientific discipline.
- Previous experience with cell therapy products and viral vector production in both adherent and suspension cell culture systems is preferred.
- A proven track record in culture process development, including cell passaging, media formulation, aseptic processing, and reagent management.
- Practical experience in hands-on process development, including the use of statistical design of experiments, is essential. Familiarity with automation technologies is a plus.
- Practical knowledge of cGMP manufacturing operations and fluency in regulatory requirements is desired.
- Strong ability to collaborate effectively within cross-functional teams in a fast-paced and dynamic environment.
