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Lead Discovery Scientist
2 months ago
Bristol-Myers Squibb is a leading biopharmaceutical company that is transforming patients' lives through science. We are seeking a highly motivated and experienced Senior Biotherapeutics Scientist to join our Discovery Biotherapeutics team.
About the Role- Lead and carry out laboratory experiments related to antibody-drug conjugation, purification, and analytical characterization.
- Design, produce, and characterize antibody-drug conjugates (ADCs) with a high degree of independence.
- Proactively advise and share knowledge with bench scientists, peers, and senior management.
- Mentor staff in troubleshooting strategic and experimental issues.
- Record of leading project teams through different stages of pre-clinical discovery.
- Ensure highest standard of quality in antibody-conjugate productions in alignment with product development guidelines and QC criteria.
- Collaborate with a diverse team of biologists and chemists to answer scientific questions and drive forward new conjugation platforms.
- Leverage knowledge of bioconjugation and protein engineering to develop new therapeutic ADC technologies.
- Develop and execute laboratory experiments to advance ADC discovery and development.
- Design and implement purification strategies using various chromatographic techniques.
- Analyze and interpret data from SEC, RP-HPLC, LC-MS, CE-SDS, ELISA, DSC, and HIC.
- Collaborate with cross-functional teams to develop and implement ADC characterization strategies.
- Develop and maintain expertise in bioconjugation chemistries, including lysine, inter-chain cysteine, and site-specific cysteine.
- Bachelor's Degree with 8+ years of academic or industry experience, or Master's Degree with 6+ years of academic or industry experience, or PhD with 4+ years of academic or industry experience.
- Extensive hands-on experience with therapeutic antibody and ADC discovery.
- Deep knowledge of bioconjugation chemistries.
- Experience in development of purification strategies using various chromatographic techniques.
- Experience in analytical characterization of ADCs.
- PhD with 4+ years of industry experience.
- Hands-on experience with siRNA/ASO conjugations and analytics.
- Demonstrated record of scientific accomplishments and publications.
- Excellent written and oral communication skills and ability to interpret results and contribute to multidisciplinary biologics discovery teams.
- Competitive compensation package.
- Opportunities for professional growth and development.
- Collaborative and inclusive work environment.
- Access to cutting-edge technology and resources.
Bristol-Myers Squibb is an equal opportunities employer and welcomes applications from diverse candidates. We are committed to creating an inclusive and supportive work environment that allows our employees to thrive.
