PET Radiochemist

1 month ago


Boston, Massachusetts, United States Brigham and Women's Hospital Full time
Job Summary

The Staff PET Radiochemist is a key member of the Brigham and Women's Hospital team, responsible for the production and quality control of novel and literature radiotracers for clinical and pre-clinical use. This role requires a strong background in chemistry, with expertise in radiolabeling and radiopharmaceutical manufacturing processes.

Key Responsibilities
  • Collaborate with the Director of Radiochemistry Research & Development to select potential compounds of interest and develop a budget and schedule to bring them into use for pre-clinical and/or human studies.
  • Work with BICOR management and Principal Investigators to define, budget, and introduce new equipment for project-specific production and quality control testing needs.
  • Develop and optimize radiochemical syntheses and analytical methods to support candidate novel and literature molecular imaging biomarkers.
  • Conduct quality control tests as needed to support research projects and ANDA radiopharmaceutical batch release.
  • Develop and properly complete appropriate SOPs and batch records for compounds of interest.
  • Define adequate levels of chemicals and disposables for new compounds and set up receiving, quarantining, and qualification of chemistry reagents and materials in accordance with cGMP.
Requirements
  • BS in Chemistry with a minimum of 6+ years of direct experience in PET IND radiosynthesis meeting the requirements of USP and/or 21 CFR 212.
  • MS in Chemistry with a minimum of 3+ years of experience in organic synthesis of compounds, radiometal chemistry, analytical chemistry, or other field applicable to chemical synthesis or quality control.
  • MS/PhD in Chemistry with a minimum of 2+ years of direct experience in PET IND radiosynthesis meeting the requirements of USP and/or 21 CFR 212.
Preferred Qualifications
  • Post-graduate experience in radiochemical synthesis.
  • Experience in quality control methodology for quantification and identity of chemical moieties in analytical samples.
  • Experience with the production of C-11, N-13, and F-18 PET radiopharmaceuticals.
  • Experience with automated synthesis units for F-18 and C-11 radiopharmaceuticals.
  • Strong competence in PET radiopharmaceutical quality control methodology.
Working Conditions

The Staff PET Radiochemist will work in a fast-paced environment, with a high level of attention to detail and a strong commitment to quality and safety. The ideal candidate will be able to work independently and as part of a team, with excellent communication and problem-solving skills.


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