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Director, Immunotherapy/Immuno-Oncology, In Vitro Pharmacology
1 month ago
Takeda is seeking a highly experienced Director to lead our Immunotherapy and Immuno-Oncology in vitro pharmacology team. As a key member of our R&D organization, you will be responsible for evaluating the biological activity of potential therapeutics candidates and selecting the best candidates for further preclinical and clinical development.
You will lead a team responsible for designing and implementing in vitro pharmacological assays, utilizing state-of-the-art technologies and methodologies, to lead the discovery of novel biologics and contribute to the strategic direction of our Immunotherapy and Immuno-Oncology research programs.
Key Responsibilities:- Provide strategic direction and leadership for the Immunotherapy and Immuno-Oncology in vitro pharmacology team, ensuring alignment with company goals and objectives.
- Lead the design, development, optimization, and execution of high-quality in vitro pharmacology assays to evaluate the activity, mechanism of action, and efficacy of Immunotherapy and Immuno-Oncology therapeutics.
- Develop and implement strategies to enhance the in vitro pharmacology capabilities and throughput, staying abreast of the latest scientific advancements and industry trends.
- Lead the Immunotherapy and Immuno-Oncology biologics discovery programs with cross-functional teams, driving the programs from lead ID to preclinical development.
- Oversee the screening and profiling of biologic drug candidates in relevant in vitro models, including immune cell-based assays, co-culture systems, and 3D organoid models.
- Investigate the molecular mechanisms underlying the activity of therapeutic candidates using in vitro pharmacology approaches, characterizing interactions with immune targets, signaling pathways, and immune cell subsets.
- Collaborate closely with interdisciplinary discovery teams, including biologics engineering, biologics production, analytics, translational scientists, and preclinical development teams to advance discovery programs.
- Mentor and develop junior scientists, fostering a culture of innovation, collaboration, and scientific excellence.
- PhD degree in immunology, cancer biology, or a related scientific discipline with 10+ years of experience, or MS with 16+ years of experience, or BS with 18+ years of experience.
- Minimum of 10 years of experience in Immunotherapy/immuno-oncology research, with a focus on immune cell biology, immune checkpoints, and tumor-immune interactions.
- Minimum of 7 years of management experience.
- Expertise in drug discovery and development processes, including hit identification, lead optimization, candidate selection, and preclinical development.
- Proven track record of leading successful in vitro pharmacology efforts in the field of immunotherapy/immuno-oncology, including assay development and validation, candidates screening, and mechanism of action studies.
- Strong technical proficiency in a wide range of in vitro pharmacology techniques and assay formats.
- Excellent leadership, communication, and interpersonal skills, with the ability to lead a team and projects and collaborate effectively across disciplines.
- Knowledge of regulatory requirements and guidelines for drug discovery and development.
Takeda is a patient-focused company that is transforming patient care through the development of novel specialty pharmaceuticals and best-in-class patient support programs. We are a global Top Employer, offering stimulating careers, encouraging innovation, and striving for excellence in everything we do.
We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.
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Takeda Compensation and Benefits Summary
We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.
For Location:
Boston, MAU.S. Base Salary Range:
$169, $266,200.00The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.
U.S. based employees may be eligible for short-term and/or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others.
EEO Statement
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
