Research Scientist

7 days ago


Bothell, Washington, United States Pfizer, S.A. de C.V Full time

Pfizer, S.A. de C.V is a global pharmaceutical company that has been at the forefront of innovation in the healthcare industry for over 170 years.

Our mission is to deliver breakthroughs that change patients' lives, and we are committed to discovering and developing new medicines and vaccines that improve human health.

We are currently seeking a highly skilled Research Scientist to join our Oncology Drug Development team in Bothell, WA.

About the Role

This is an exciting opportunity to work on pre-clinical drug discovery and development projects with a focus on ADC Biology and Cancer Immunology.

You will be responsible for working with project teams to design, plan, and execute an in vivo strategy to ensure efficient and effective decision-making.

You will also be a key stakeholder/contributor to the In Vivo Committee, responsible for vetting study designs and strategies and ensuring timely completion of research project objectives.

Key Responsibilities

  • Collaborate across project teams to establish in vivo strategy and study plans for drug discovery projects.
  • Serve as the in vivo pharmacology lead for several drug discovery projects.
  • Ensure that projects have all critical in vivo data to enable project stage-dependent decisions.
  • Work within multi-functional teams to support target identification, validation, drug discovery, and combination therapy.
  • Work across in vivo teams in a highly collaborative manner, sharing expertise and resources to meet study needs across In Vivo Pharmacology.
  • Design and conduct in vivo studies to evaluate and establish efficacy, PK/PD relationship, combination strategy, biomarker identification, and analysis.
  • Supervise and guide a small team of scientists.
  • Develop and characterize new in vivo mouse models, including cell-line-derived xenografts, syngeneic tumor, and genetically engineered mouse (GEM) models, to study biologic mechanisms and support exploration of novel cancer immune therapeutics and targeted therapies.
  • Ensure team members comply with all regulatory requirements and internal policies.
  • Facilitate and lead the development and execution of ancillary in vitro assays necessary to maximize value of the contribution by the in vivo team, if necessary.
  • Interpretation, presentation, and documentation of experiments as well as preparation of reports.
  • Written and verbal presentation of results within a multidisciplinary team environment.
  • Contribute to relevant in vivo sections of study reports and regulatory documents, e.g., IND filings.
  • Publish results in scientific peer-reviewed journals and presentations at internal, national, and international meetings.

Requirements

  • Must-Have:
    • Ph.D. in Cancer Biology, Immunology, Genetics, or a related discipline and a minimum 5 years industry experience including technical and scientific experience in drug discovery and preclinical development, or
    • MS in Cancer Biology, Immunology, Genetics, or a related discipline and a minimum 10 years industry experience including technical and scientific experience in drug discovery and preclinical development, or
    • BS in Cancer Biology, Immunology, Genetics, or a related discipline and a minimum 13 years industry experience including technical and scientific experience in drug discovery and preclinical development.
  • Experience in collaborative research in Oncology drug discovery programs.
  • Experience with animal models of human cancers.
  • Hands-on in vivo (e.g., IV, PO dosing, blood/tissue collection) and ex vivo skills (e.g., flow cytometry, western blot, ELISA).
  • Experience supervising a small team of Scientists.
  • Excellent written and oral communication and presentation skills.
  • Proficiency with all common office and scientific software.

Preferred Qualifications

  • Strong track record of publications or evidence of equivalent achievements in industry.
  • Experience with GEMM and humanized models.
  • Experience with Antibody Drug Conjugates (ADC).

About Pfizer, S.A. de C.V

Pfizer, S.A. de C.V is a global pharmaceutical company that offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues.

We provide a comprehensive total rewards package, which includes salary, bonus, stock, retirement savings, and more.

Estimated annual salary range: $140,000-$200,000 depending on experience and qualifications.



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