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Principal Research Associate in Cell Therapy
2 months ago
Position Overview:
Key Responsibilities:
- Design and validate flow cytometry-based assays aimed at comprehensive characterization of immune cell biology and functionality, including the development of Standard Operating Procedures (SOPs) and detailed technical documentation.
- Collaborate with Quality Control teams to enhance methodologies, troubleshoot issues, conduct root cause analyses, and oversee method validation and lifecycle management.
- Assist the Product Development team in creating assays to assess process and product characteristics.
- Engage in testing of clinical manufacturing materials, provide method training and transfer, analyze data, troubleshoot challenges, and conduct thorough reviews.
- Participate in technology transfer initiatives with both internal and external collaborators.
- Meticulously execute and document laboratory procedures and experiments, ensuring comprehensive record-keeping through Electronic Lab Notebooks (ELN).
Required Qualifications:
- Background in cell therapy, immunology, or a related discipline; PhD with 0-2+ years of experience (MS with 4+ years or BS with 6+ years considered); prior experience in the industry is preferred.
- Desirable experience in cell and gene therapy within an Analytical Development capacity.
- Technical proficiency in flow cytometry and cell sorting; familiarity with antigen density quantification, phospho-flow, or co-culture assays is advantageous.
- Experience in the development and qualification of flow-based methodologies.
- Proficient in MS Word, Excel, PowerPoint, and scientific data analysis tools such as GraphPad Prism and NovoExpress/FCS Express.
- Capability to thrive in a dynamic and fast-paced work environment.
*Comprehensive job description available upon request.*