Senior Research Scientist

2 weeks ago


Reston, Virginia, United States R&D Partners Full time

Conjugation Process Development Opportunity

R&D Partners is seeking a highly skilled Scientist I, II, or Sr. to contribute to the development of conjugation processes for our pneumococcal conjugate vaccine program. The successful candidate will have significant laboratory experience and an excellent understanding of analytical chemistry principles.

Main Responsibilities:

  • Optimize and troubleshoot multi-step syntheses of protein-polysaccharide conjugates.
  • Purify polysaccharides and conjugates using various methods, including dialysis, size-exclusion chromatography, and tangential flow filtration (TFF).
  • Analyze polysaccharides and conjugates with various analytical methods, developing new laboratory workflows and analyses as needed.
  • Advise team members on experimental design, result interpretation, and troubleshooting.
  • Model and train team members on best practices for protocol adherence and data management.
  • Serve as a subject matter expert during tech transfer of conjugation processes to contract manufacturing organizations.
  • Maintain highly organized records to enable optimization and assessment of reproducibility.
  • Attend team meetings to provide updates on conjugation development progress.

Requirements:

  • PhD in chemistry, biochemistry, or related field with 2-5+ years of industry experience, MS with 5-8+ years, or BS with 10+ years of experience.
  • Strong biochemistry and organic chemistry knowledge base with several years' experience preparing bioconjugates.
  • Proficiency with small- and large-scale techniques for purification of bioconjugates, including tangential flow filtration.
  • Proficiency in various techniques for bioconjugate analysis, such as colorimetric assays, HPLC, and SEC-MALS.
  • Sufficient knowledge of analytical principles to develop fit-for-purpose analytical methods as needed and provide cross-functional feedback on draft analytical methods.
  • Experience with Design of Experiments is desirable.
  • Experience with chemical modification of polysaccharides is desirable.

Compensation:

$120,000- $160,000 annually

R&D Partners is a global functional service provider and strategic staffing resource specializing in scientific, clinical research & engineering. We provide job opportunities within major pharmaceutical, biopharmaceutical, biotechnology, and medical device companies.

R&D Partners is an equal-opportunity employer.



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