About XBiotech USA, Inc.

XBiotech USA, Inc. is a leading drug Research & Development organization based in Austin, Texas. Our facility encompasses all essential operations including discovery, research and development, drug testing, product formulation, and clinical-regulatory affairs.

As a fully integrated biopharmaceutical entity, XBiotech conducts all activities from preclinical models to clinical trial execution and manufacturing under one roof. Our focus is on developing antibody therapeutics that address significant medical needs in inflammatory diseases and cancer.

Who We Are Looking For:

XBiotech is in search of a highly driven and intelligent Scientist to join our Rodent Pharmacology-Toxicology team. This team is responsible for designing and developing animal models for cancer, inflammation, and infectious diseases to evaluate novel drugs identified through our discovery pipeline. Additionally, the team conducts in vivo nonclinical safety studies, which vary from acute to chronic durations, in compliance with Good Laboratory Practices (GLP).

Success in our environment hinges on passion for your work. Candidates must possess strong multitasking abilities and high energy levels. Creativity and open-mindedness are essential traits in this role. The position requires a commitment to a five-day work week, including rotational weekend and holiday coverage.

Key Responsibilities:

• Design, execute, and analyze innovative research in the fields of in vivo pharmacology and toxicology to support XBiotech's research pipelines in Inflammatory, Oncology, and Infectious diseases.
• Conduct in vivo rodent studies to assess the pharmacokinetics and pharmacodynamics of antibody therapeutics.
• Plan and implement toxicology and safety pharmacology studies utilizing rodent models.
• Design and perform in vivo studies to establish the efficacy of new therapeutics in inflammation, oncology, and infectious diseases.
• Engage in hands-on tasks including animal handling, administering test substances via various routes, monitoring animal health, and collecting and processing samples while ensuring accurate data documentation.
• Perform full body necropsies and collect organs and tissues for histopathological analysis.
• Implement study protocols in accordance with IACUC guidelines and maintain compliance with IACUC and AAALAC regulations.
• Execute ex vivo techniques such as flow cytometry, western blotting, and ELISA, if applicable.
• Maintain meticulous laboratory records and documentation.
• Draft Standard Operating Procedures and adhere to Good Laboratory Practices.
• Analyze and interpret scientific data, effectively communicating findings to project teams and regulatory bodies.
• Work independently and solve problems without direct supervision on routine tasks.
• Demonstrate attention to detail and innovative thinking.

Qualifications:

• Ph.D. in pharmacology, toxicology, or a closely related scientific discipline.
• A minimum of five years of experience in nonclinical development, toxicology, or veterinary medicine within the pharmaceutical, biotechnology, or contract service sectors.
• Proficient in in vivo techniques (e.g., IV, IP, SC dosing, blood/tissue collection) and ex vivo methodologies (e.g., flow cytometry, western blot, ELISA).
• Ability to work effectively both independently and within a team environment with minimal supervision.
• Willingness to work weekend shifts and during off-hours as needed.
• Ensure timely completion of studies in alignment with project timelines.
• Familiarity with regulatory guidance documents, precedents, and GLP regulations.
• Strong communication skills with the ability to address scientific and regulatory inquiries under pressure.
• Detail-oriented with a capacity for critical and innovative thinking.
• A genuine passion for scientific research.

Work Environment:

• Fast-paced and dynamic.
• Ability to manage projects with minimal supervision.
• Capability to multitask effectively.

Employee Value Proposition:

• Engage in the development of groundbreaking drugs that have the potential to benefit millions globally.
• Utilize cutting-edge technology and streamlined manufacturing processes.
• Learn from a team of distinguished professionals with extensive experience in scientific services.
• Collaborate with experts in R&D, manufacturing, drug implementation, and management.
• Be part of a pioneering effort in the commercialization of antibody products through simplified processes.
• Experience a collaborative and friendly workplace atmosphere.
• Opportunities for professional growth and advancement.