Senior Biopharmaceutical Research Scientist
6 days ago
Valora Therapeutics Inc. is a pioneering biopharmaceutical company based in San Diego, California, USA. Our innovative platform technology enables the engineering of chimeric antibodies to unlock new mechanisms of immune signaling and activity, paving the way for transformative therapies in oncology, immune diseases, and beyond.
Job SummaryWe are seeking a highly motivated Senior Biopharmaceutical Research Scientist to support our R&D Operations in developing next-generation antibody therapeutics using our proprietary chimeric antibody platform. This role will focus on hands-on laboratory work and will include activities such as the design and execution of experiments to evaluate novel engineered antibodies, applying critical thinking and problem-solving skills.
Responsibilities- Assist in the design and execution of experiments to evaluate novel engineered antibodies.
- Develop and optimize in vitro and ex vivo assays to elucidate cellular and molecular immunological mechanisms.
- Analyze datasets, interpret results, and contribute to presenting findings to cross-functional teams.
- Contribute to the development of new hypotheses and experimental approaches in team discussions.
- Stay current with advancements in immunology and antibody engineering, applying this knowledge to ongoing projects.
- Minimum requirements: Master's degree with 4+ years of experience, or bachelor's degree with 6+ years of experience in an academic or biopharmaceutical industry setting.
- Strong foundation in cellular and molecular immunology, with experience in NK cell, macrophage, or T cell biology.
- Understanding of immuno-oncology concepts and mechanisms.
- Knowledge of glycobiology and glyco-immunology is desirable.
- Proficiency in the following laboratory techniques:
- a) Functional assays such as: (1) Cytotoxicity assays (e.g., 51Cr release, LDH release, real-time cell analysis), (2) Proliferation assays (e.g., CFSE dilution, 3H-thymidine incorporation), (3) Cytokine production and secretion assays (e.g., ELISPOT, intracellular cytokine staining), (4) Antibody-dependent cellular cytotoxicity/phagocytosis (ADCC/ADCP) and complement-dependent cytotoxicity (CDC) assays
- b) Multi-color flow cytometry for immunophenotyping and functional readouts.
- c) MSD, Luminex, or other multiplex assays for analyte measurement.
- d) Molecular immunology assays to interrogate signaling pathways and evaluate mechanisms of action.
- Experience with primary cell isolation and culture techniques.
- Familiarity with antibody engineering concepts and methods, including Fc engineering for enhanced effector functions, Bispecific and multi-specific antibody formats, etc.
We offer a competitive salary range of $120,000 - $160,000 per year, depending on experience, plus a comprehensive benefits package, including medical, dental, vision, and supplemental disability insurance. Additionally, you will receive bonus pay and stock options as part of your compensation package.
This is a full-time position, requiring a minimum of 5 days per week presence at our laboratories. We offer flexible schedule and a collaborative and supportive team environment with a highly dynamic and entrepreneurial environment.
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