Lead Translational Researcher Precision Medicine

5 days ago


Worcester, Massachusetts, United States AbbVie Full time
Job Description

As a highly motivated and creative Scientist with a scientific background in immunology or immuno-oncology, you will join our Precision Medicine Translational Research Immunology Group as Principal Scientist at AbbVie. Your primary responsibility will be to provide leadership in clinical biomarker strategy and assay development in inflammatory/autoimmune disease areas, including Dermatology, Gastroenterology, Rheumatology, and Fibrosis for AbbVie's drug development programs from late discovery to clinical trials.

  • Lead biomarker strategies through cross-functional teams in a matrix environment to identify gaps and develop fit-for-purpose clinical TE/PD biomarker, predictive, and exploratory biomarker assays to support human dose projection and establish early signs of efficacy in clinical trials and patient selection strategies.
  • Collaborate with Data Science team and Precision Medicine lead to analyze internal and external omics data, understand heterogeneity of diseases, identify disease endotypes, support disease strategy, and generate patient selection and combination hypotheses for further testing with preclinical studies.
  • Develop preclinical patient-derived disease models, design studies with appropriate controls and endpoints to understand drug target mechanisms for PD biomarker development and evaluate biomarker hypotheses and combination strategies.
  • Serve as a subject matter expert in analytical methodologies/technologies for translational research, including single cell and spatial omics, proteomics, methylomics, metabolomics, genomics, NGS, MSD, ELISA, Luminex, flow cytometry, ex vivo primary cell culture, and organoid-immune cell culture.
  • Manage external CROs and academic collaborations, including study proposal, budget, timeline, and data review.
  • Manage and coach a team of translational scientists, ensuring the successful execution of translational research plans across multiple projects.
  • Stay up-to-date with the latest research & development in inflammatory and immune diseases through critically reviewing literature, attending conferences, and seeking advice from KOLs.


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