LC-MS/MS Method Development Expert

6 days ago


Exton, Pennsylvania, United States Frontage Laboratories Full time

Job Summary:

The Senior Bioanalytical Scientist position at Frontage Laboratories supports method development using LC-MS/MS platform for large molecules (biomarkers, proteins, antibodies, ADCs, Oligonucleotides, etc). This role involves serving as a subject matter expert, reviewing client requests, developing methods, transferring them to the validation team, and troubleshooting challenging methods.

About Frontage Laboratories:

Award-winning Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China. Our core competencies include drug metabolism, pharmacokinetics/pharmacodynamics (PK/PD), safety and toxicology, bioanalytical services, chemistry and manufacturing controls for drug development, and core laboratory services for clinical trials.

Key Responsibilities:

  • Method development using LC-MS/MS platform for large molecule quantitation in biological matrices.
  • Method transfer from the method development team to the validation team.
  • Project timeline management and data communication to the Principal Investigator.
  • Multi-project handling and research for new techniques and procedures.
  • Regulatory compliance and training of junior staff.
  • Instrumentation setup, utilization, and maintenance.

Requirements and Qualifications:

  • Ph.D. or Master's degree in Analytical Chemistry, Biochemistry, Biology, or related scientific discipline.
  • 6-10 years of direct experience in bioanalytical method development for large molecules using LC-MS/MS in the biotech, pharma, or CRO industry.
  • Demonstrated experience in mass-spectrometry method development for antibodies and ADCs.
  • Excellent communication skills and ability to work in a team environment.
  • Good knowledge and application of GLP with the ability to train technical personnel.

Compensation Package:

Competitive compensation package including health and dental insurance, a 401(k) plan, disability insurance, and life insurance.



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