Senior Director: Cell Engager Portfolio Lead, ODDU

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OBJECTIVES/PURPOSE

The Oncology Drug Discovery Unit (ODDU) is looking for a Leader who will serve as Senior Director, Cell Engager Portfolio Lead reporting into the Solid and Heme Tumor Targeted Therapies Drug Discovery Lead. The individual should have strong Drug Discovery experience applying a disease-first strategy focused on understanding and exploiting the underlying mechanisms of a disease to develop lead assets while training a skilled scientific team.  This strategic leader is able and willing to contribute to projects moving from target identification and validation through early clinical proof of concept.

This candidate will have a deep comprehension of biology (immuno-oncology biology, biologics, translation), strong leadership skills, the ability to apply innovative research biology approaches to provide scientific insights, and the ability to think critically about long-term strategy anticipating the future needs in the field of cell engagers and beyond. The candidate will also serve on the scientific leadership team of the ODDU and is responsible for peer review of data package plans, agreement on innovation priorities, generating clear data package expectations that enable the ability to easily track progress and address potential issues.  The candidate is expected to be influential across the entire drug discovery spectrum in Research (beyond Oncology).  Using their enterprise mindset, the candidate will in partnership with other Research functions help to accelerate development of Takeda's discovery portfolio and in partnership with other therapeutic areas to accelerate development of Takeda’s discovery portfolio.

ACCOUNTABILITIES

• This leader will be responsible for leading research for selected innovative cell engager and targeted therapies at Takeda and will work closely with Research and Development project teams, Portfolio Leads, Discovery Leads and Lab Heads to develop the strategies and to enable execution of robust, decision-enabling preclinical and translation experiments.
• The leader is expected to develop, define, and effectively communicate the vision and strategy of the Cell Engager team as it relates to contributing to an industry-leading research portfolio in collaboration with other Portfolio Leads across the DDU.
• Builds and mentors a team tailored to the vision and strategic imperatives of the ODDU.
• The leader is a scientific driver for research strategy that brings in external innovation to supplement internal pipeline priorities in partnership with CEI (Center for External Innovation)
• Oversee the work of Discovery Leads, Lab Head and team providing feedback and detailed scientific guidance and taking corrective action as needed.
• Develop, drive, and execute the Research plans for selected cell engager programs to support pre-IND packages for the DDU portfolio in partnership with Discovery Leads and Lab Head and team.
• Represent ODDU within R&D and the TAU, as well as to external stakeholders with respect to the cell engager programs being supported.
• Drive and deliver the pre-clinical development of cell engager programs and across the ODDU portfolio, leveraging resources as needed on key ODDU initiatives and assets. 
• Serve as an experienced thought leader for Immuno-Oncology & Translational Oncology within Takeda, guiding the research strategy and ensuring its successful execution while supporting talent development as a strong mentor and role model for cell engager research.
• Develop and deliver on the design, execution, and analysis of mechanism of action and proof-of concept studies, in close partnership across ODDU, R&D, and the TAU, including perspective across the continuum of discovery and development with a global perspective.
• Support business critical decision making for pre-IND packages within the cell engager pipeline, and the broader Takeda ODDU portfolio.
• Leverage up-to-date knowledge of drug development and competitive landscape at internal governance bodies as well as at key interfaces with external partners, to guide decision making.
• Drive biology focus with solid translation and clinical path in partnership with Research and TAU (Therapeutic Area Unit) partners.
• Provide direction for the identification of new targets aligned with the iDAS (integrated disease area strategy) in collaboration with the Oncology Development Therapeutic Area Unit and the Oncology Business Unit.​
• Provide significant input into overall ODDU portfolio and department strategy.
• Provide leadership and strategic support across Research, and/or to external collaborators.
• Responsible for management of resourcing and budget planning for the cell engager field.
• Ability to work in a highly matrixed environment and establish robust connections between the biology and translational team, engaging cross-functional teams to support projects.
• Work closely with in-house and external partners in developing solid translational and research plans, in interpreting results, and in determining next steps to maximize patient-centered value of the portfolio.

EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:  

• PhD in Immunology or related field with 12+ years of industry experience.
• 7 (Director)-9 (Senior Director) years of Industry experience required, and 7 (Director)-9 (Senior Director) years of managerial experience required.
• Excellent knowledge in biologics, immunology, oncology, and drug discovery is required.
• Excellent oral and written communication skills, including writing, reviewing and editing scientific documents and presenting to a range of stakeholders.
• Ability to work and drive decision-making within a multi-disciplinary, multi-regional, matrix teams with a global perspective with cultural competency.
• Good fit with Takeda core values and leadership principles, including the highest personal values and ethical standards.
• Takeda’s high-engagement and ONE Research DEI culture is an important factor in our success; we seek team members who will contribute to and further strengthen that culture in all ways of working.
• Right attitude (agile, curious, positive, open-minded, “can-do” mindset), must be willing and able to be “hands on,” results-oriented mindset.
• Effective leadership, people management, communication skills, and a team builder management style are essential.
• Ability to take an enterprise mindset to enable the success of Takeda.

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Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. 

For Location:

U.S. Base Salary Range:

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. 

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. 

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.