Flow Cytometry Test Developer

5 days ago

Boston, United States Brigham and Women's Hospital Full time

The Integration and Test Development Lead, Mass General Brigham (MGB) Flow Cytometry, reporting to the Medical Directors of the MGB Flow Cytometry Laboratory and Brigham and Women's Hospital (BWH) Hematology Laboratory, is functionally responsible for flow cytometry clinical test integration across the MGB network, including new test design, development, and implementation, and also supports lab operational management with associated quality assurance activities. Clinical activities will take place primarily at the MGB Flow Cytometry Laboratory currently located in the BWH Department of Pathology. The incumbent will also oversee and support flow cytometry training and educational activities within the MGB Flow Cytometry Laboratory and the entire MGB network. The position does not perform daily clinical testing.
MGB Flow Cytometry Laboratory Integration
* Interacts collaboratively with laboratory medical directors and hematopathologists to oversee the development, direction, and expansion of the enterprise-wide Flow Cytometry Integrated Laboratory Service (ILS) currently based primarily at BWH.
* Interacts collaboratively with laboratory directors and hematopathologists to develop and optimize workflows, standard operating procedures, and quality metrics within the MGB Flow Cytometry ILS.
* Oversees the design, standardization, optimization, and validation of clinical flow cytometry laboratory test panels and templates within the MGB Flow Cytometry ILS, seeking collaborative input from AMC and community-based hematopathologists as needed.
* Oversees the validation and integration of new diagnostic assays into the clinical flow cytometry laboratory framework, including measurable residual disease (MRD) monitoring, myelodysplastic syndrome (MDS) assessment, cell sorting for FISH and molecular applications, DNA ploidy, and flow cytometry-based functional assays.
* Oversees insourcing of flow cytometry testing currently being sent outside of the MGB enterprise to the Flow Cytometry ILS, beginning with MGH volume follow by MGB community volume, ensuring that needs of pathologists, providers, and patients at each site are met.
* Proactively identifies areas that are potentially problematic, challenging, or inefficient in the enterprise-wide operation; presents alternative solutions and helps to create plans to address these issues.
* Identifies and evaluates flow cytometry reagents, instrumentation, and software, ensuring that appropriate regulatory guidelines are met.
* Participates in MGB Flow Cytometry ILS meetings, Beaker Flow Cytometry meetings, meetings with Laboratory Information Systems (LIS) staff for issues pertaining to flow cytometry, panel design/development meetings with MGB hematopathologists, and other meetings as needed.
* Monitors quality of work performed within the MGB Flow Cytometry ILS and develops, collects, and reports relevant metrics evaluating laboratory performance in conjunction with BWH Hematology Clinical Lab Manager.
* Provides support to BWH-based laboratory supervisory team with validation of new flow cytometry instrumentation, instrument troubleshooting and maintenance, quality control, calibration, integrity of performance, and data output.
* Provides support for MGH-based flow cytometry testing housed within MGH HLA Laboratory, including assisting with instrument maintenance and troubleshooting, reagent inventory and purchasing, staff training and support, and quality assurance.
* Major role in regional outreach on behalf of the MGB Flow Cytometry ILS, including development of business plan for reference laboratory testing, with the goal of becoming a regionally and nationally reputable flow cytometry reference laboratory and Center of Excellence.
Training and Education
* Major role in flow cytometry training and education, including formal and informal teaching of medical laboratory scientists (MLS) and other technical personnel, residents, and hematopathology fellows and faculty.
* Provides training, mentorship, guidance, and support to technical flow cytometry personnel, including formal and informal teaching, development of training plans and competency assessments, and development and execution of teaching sessions focused on case work-up, basic analysis and higher-level functions, such as advanced instrument troubleshooting, work-up and analysis of complex cases, MRD analysis, and new panel design and development.
* Arranges for in-service education, training, and lectures for various groups (MLS and other technical personnel, residents, and hematopathology fellows and faculty) appropriate to their roles and levels of knowledge and expertise.
* Identifies educational and instructional opportunities through the American Society for Clinical Pathology (ASCP), International Clinical Cytometry Society (ICCS), Society for Hematopathology (SH), International Society for Laboratory Hematology (ISLH), and other professional organizations through new and established contacts.
* Works collaboratively with MGB MLS training program leadership to provide flow cytometry training and education to students within the MGB MLS training program.
* Provides input into technical staff performance reviews and competency assessments in collaboration with lab management.
* Provides input into recruitment of new technical staff, in collaboration with laboratory medical leadership and HR.
* Supports cross-training of technical staff in different aspects of flow cytometry and with various other laboratory areas in response to operational needs and to promote staff development and retention.
Compliance
* Supports the MGB Flow Cytometry Laboratory and the MGH HLA Laboratory as needed in Joint Commission inspection readiness.
Assists lab operational leadership in the identification and investigation of flow cytometry-related quality and safety (Q&S) concerns in collaboration with MGB Quality and Patient Safety and aids in the investigation of Q&S concerns brought forward by other parties.

Requirements:

Master's or PhD Degree in biology, biotechnology, immunology, education, or related discipline.

Minimum 10 years of experience in Flow Cytometry or a related field.

Working Conditions:

*Multi-site role within metro Boston area: on-site work primarily performed at the MGB Flow Cytometry Laboratory located at BWH. Presence may occasionally be needed at MGH HLA Lab to provide support or other MGB sites for in-person meetings or trainings. Primary work location may change over time depending on evolving departmental and system-wide priorities, needs, and initiatives in flow cytometry.

*Clinical laboratory setting: May be exposed to disease-bearing specimens, hazardous chemicals/fumes, and other hazards normally found in a clinical lab setting.

*Staff work in close physical proximity to one another.

*Ability to lift and carry 20 lbs.

Additional Job Description

The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

  • Senior Research and Development Biologist

    4 weeks ago

    Boston, Massachusetts, United States Takeda Pharmaceutical Full time

    Job OverviewWe are seeking an experienced Senior Scientist to join our team in Boston, MA. As a key member of our Global Biologics team, you will play a crucial role in the development of novel therapeutic antibodies using cutting-edge flow cytometry technology.About UsTakeda Pharmaceutical is a global leader in the biopharmaceutical industry, dedicated to...

  • Co-Director or Associate Director, Hematology Laboratory and Hemopathology

    2 months ago

    Boston, United States Boston Children's Hospital Full time

    The Departments of Laboratory Medicine (DLM) and Pathology at Boston Childrens Hospital (a teaching affiliate of Harvard Medical School) are seeking a Hemopathologist with the appropriate training, experience, and established skill set to join the faculty as a Co-Director or Associate Director of the Hematology Laboratory in DLM and member of the...

  • Antibody Discovery Specialist

    1 week ago

    Boston, Massachusetts, United States Lifelancer Full time

    **Unlock Innovation in Antibody Discovery**Takeda's Global Biologics team is a world-leading RD organization dedicated to unlocking innovation and delivering transformative therapies to patients worldwide. As a Antibody Discovery Specialist, you will join this dynamic team to develop innovative solutions to complex problems aligned with organizational...

  • Biologics Researcher

    1 week ago

    Boston, Massachusetts, United States Lifelancer Full time

    **Global Biologics Team**Takeda's Global Biologics team is a forward-looking, world-class RD organization that unlocks innovation and delivers transformative therapies to patients worldwide. As a Biologics Researcher, you will join this dynamic team to develop innovative solutions to complex problems aligned with organizational objectives.Your work involves...

  • Senior Director, Head of Genomics, Cytometry,

    3 weeks ago

    Boston, United States Takeda Pharmaceutical Full time

    By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge. Job...

  • Stability Program Manager

    1 week ago

    Boston, Massachusetts, United States CRISPR Therapeutics Full time

    About the PositionWe are seeking a highly skilled Senior Quality Control Stability Specialist to join our team. This is a key role in ensuring the stability program is compliant with regulatory requirements.Responsibilities & RequirementsResponsible for ensuring the stability program is compliant with regulatory requirements.Collaborate with cross-functional...

  • Senior Molecular Biology Research Associate

    3 weeks ago

    Boston, Massachusetts, United States Centaura Full time

    Job OverviewWe are seeking a highly motivated and experienced Senior Molecular Biology Research Associate to join our team at Centaura.Key Responsibilities:Experiment Support: Provide technical expertise and support for ongoing experiments, including the construction and delivery of Human Artificial Chromosomes (HACs) into human cells, as well as designing...

  • Immunologist

    1 month ago

    Boston, United States HireMinds Full time

    Scientist, ImmunologyLocation: Boston, MAHireMinds is seeking a motivated Senior Associate Scientist or Scientist to join our client's discovery to preclinical efforts in the lab. In this role you’ll provide MOA study support, preclinical, and translational immunology experiment expertise in the lab. You’ll work on a novel platform in cancer and...

  • Immunologist

    4 weeks ago

    Boston, United States HireMinds Full time

    Scientist, Immunology Location: Boston, MA HireMinds is seeking a motivated Senior Associate Scientist or Scientist to join our client's discovery to preclinical efforts in the lab. In this role youll provide MOA study support, preclinical, and translational immunology experiment expertise in the lab. Youll work on a novel platform in cancer and autoimmune...

  • HireMinds | Scientist, Immunology | boston, ma

    2 months ago

    boston, United States HireMinds Full time

    Scientist, Immunology Location: Boston, MAHireMinds is seeking a motivated Senior Associate Scientist or Scientist to join our client's discovery to preclinical efforts in the lab. In this role you’ll provide MOA study support, preclinical, and translational immunology experiment expertise in the lab. You’ll work on a novel platform in cancer and...

  • HireMinds | Immunologist | boston, ma

    1 month ago

    boston, United States HireMinds Full time

    Scientist, ImmunologyLocation: Boston, MAHireMinds is seeking a motivated Senior Associate Scientist or Scientist to join our client's discovery to preclinical efforts in the lab. In this role you’ll provide MOA study support, preclinical, and translational immunology experiment expertise in the lab. You’ll work on a novel platform in cancer and...

  • Scientist, Immunology

    1 month ago

    Boston, United States HireMinds Full time

    Scientist, Immunology Location: Boston, MAHireMinds is seeking a motivated Senior Associate Scientist or Scientist to join our client's discovery to preclinical efforts in the lab. In this role you’ll provide MOA study support, preclinical, and translational immunology experiment expertise in the lab. You’ll work on a novel platform in cancer and...

  • Fable Therapeutics | Scientist, Cell-based Assays

    1 month ago

    boston, United States Fable Therapeutics Full time

    About Us:Fable Therapeutics (Fable) is a discovery-stage biotechnology company which develops non-cell-based therapeutic response where and when it matters.Fable is powered by state-of-the-art structure and sequence-based protein language models. Founded by leading ML scientists and veteran biotech entrepreneurs together with top-tier venture capital firms,...

  • Scientist, Cell-based Assays

    6 days ago

    Boston, United States Fable Therapeutics Full time

    About Us:Fable Therapeutics (Fable) is a discovery-stage biotechnology company which develops non-cell-based therapeutic response where and when it matters.Fable is powered by state-of-the-art structure and sequence-based protein language models. Founded by leading ML scientists and veteran biotech entrepreneurs together with top-tier venture capital firms,...

  • Scientist, Cell-based Assays

    1 month ago

    Boston, United States Fable Therapeutics Full time

    About Us:Fable Therapeutics (Fable) is a discovery-stage biotechnology company which develops non-cell-based therapeutic response where and when it matters.Fable is powered by state-of-the-art structure and sequence-based protein language models. Founded by leading ML scientists and veteran biotech entrepreneurs together with top-tier venture capital firms,...

  • Senior Scientist

    4 weeks ago

    Boston, United States Takeda Pharmaceutical Full time

    By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge. Job...

  • Associate Scientist, Cell-based Assays

    1 month ago

    Boston, United States Fable Therapeutics Full time

    About Us:Fable Therapeutics (Fable) is a discovery-stage biotechnology company which develops non-cell-based therapeutic response where and when it matters.Fable is powered by state-of-the-art structure and sequence-based protein language models. Founded by leading ML scientists and veteran biotech entrepreneurs together with top-tier venture capital firms,...

  • Fable Therapeutics | Associate Scientist, Cell-based Assays | boston, ma

    1 month ago

    boston, United States Fable Therapeutics Full time

    About Us:Fable Therapeutics (Fable) is a discovery-stage biotechnology company which develops non-cell-based therapeutic response where and when it matters.Fable is powered by state-of-the-art structure and sequence-based protein language models. Founded by leading ML scientists and veteran biotech entrepreneurs together with top-tier venture capital firms,...

  • Associate Scientist, Cell-based Assays

    6 days ago

    Boston, United States Fable Therapeutics Full time

    About Us:Fable Therapeutics (Fable) is a discovery-stage biotechnology company which develops non-cell-based therapeutic response where and when it matters.Fable is powered by state-of-the-art structure and sequence-based protein language models. Founded by leading ML scientists and veteran biotech entrepreneurs together with top-tier venture capital firms,...

  • Senior Scientist

    3 weeks ago

    Boston, United States Takeda Pharmaceutical Full time

    By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.Job...