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Senior Process Engineer
1 month ago
At AstraZeneca's Oncology R&D division, we follow the science to explore and innovate. We are working towards treating, preventing, modifying, and even curing some of the world's most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. We are committed to making a difference and have built our business around our passion for science. Now we are fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs.
Position Summary
The Senior Process Engineer, Process Developmentis a laboratory-based role responsible for support development of a clinical manufacturing process of engineered T cells with patient-derived neo-antigen specific TCRs. Additionally, this role evaluates technology and process improvements and plays a key role in process understanding and process characterization. Additionally, the process engineer will be involved in manufacturing support and technology transfer to ensure successful implementation in a cGMP environment. This role is based in Santa Monica, CA and reports to the Director, MSAT.
Responsibilities
- Design, execution, analysis, and documentation of early and late stage process development studies to develop, optimize, characterize and transfer cGMP manufacturing processes. Involves cell culture of T cells in multiple formats including flasks, bags, and bioreactors.
- Collaborates within the team to interpret study results and contribute to technical discussions cross functionally for subsequent study design and decision making.
- Contributes to manufacturing support efforts; including batch record and SOP development, real-time troubleshooting, investigation and impact assessment for deviations, change control management, process monitoring and data analysis, and risk assessments.
- Serves as a project/program manager with independent discretion.
- Perform other duties and special projects as assigned.
Required Skills
- Knowledge of cGMP manufacturing and regulations and practical experience in GMP
- Knowledge of QbD, DOE and statistical analysis tools (e.g. JMP, MiniTab).
- Ability to think critically, analytically and have demonstrated troubleshooting and problem- solving skills based on deductive
- Strong verbal and written communication skills, including technical writing.
Education and Experience
- BS degree in Biochemical Engineering, Biomedical Engineering, Biotechnology or related field with 6 years OR MS degree with 4 years OR PhD with 1-year relevant industry experience.
- Experience in technical development of cell and gene therapy or biologics in early and late-stage development
- Hands-on experience in cell and gene therapy, specifically in T cells is highly desirable.
The annual base salary for this position ranges from $126,000 to $157,000. However, base pay offered may vary depending on multiple individualized factors, including market location, job-related experience. If hired, employee will be in an "at-will position" and we reserve the right to modify base salary (and any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.
Benefits
- Short-term incentive bonus opportunity
- Equity-based long-term incentive program
- 401(k) plan
- Paid vacation and holidays; paid leaves
- Health benefits including medical, prescription drug, dental, and vision coverage.
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DE&I Statement
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.