Associate Director, Medicinal Chemistry

4 weeks ago

Portola Valley, United States REVOLUTION Medicines Full time

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit high-value frontier targets in RAS-addicted cancers. The companys R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.Revolution Medicines is seeking a scientifically talented individual to join our world-class Discovery Chemistry team. This position will be focusing on early hit discovery and has opportunities to play a critical role through the stages of drug discovery, including hit-to-lead, lead optimization and delivering high-quality anti-cancer drug candidates. This role is managerial, reporting into the Director, Medicinal Chemistry.The Opportunity:Propose research plans, identify critical issues, and overcome scientific challenges to advance research projectsWork closely with other medicinal chemists and cross-functional teams (Biology, DMPK, Pharmacology, Discovery Sciences, CMC) to meet the timelinesSupporting Medicinal Chemistry efforts to deliver high quality lead compounds across multiple new targets/projects via optimal Design-Make-Test-Analyze cyclesProvide research project updates and communicate effectively across functional teams at Revolution MedicinesPresent research results at scientific meetings, contribute publications in peer-reviewed literature, and prepare patent applicationsEnhance our operational efficiency & flexibility through the management of external chemistry CRO resources, continuous improvement activities and implementation of best practiceSupport a culture of creativity and commit to the Chemistry department vision to build a sustainable portfolio through transformative scientific researchManaging, coaching and mentoring scientists across the Medicinal Chemistry function in order to develop their skills and build RevMeds organizational capabilities.Required Skills, Experience and Education:Ph.D. degree in chemistryMinimum of 5 years experience in the pharmaceutical/biotech industry with a track record of scientific innovation in the medicinal chemistry disciplineWorking knowledge of modern medicinal chemistry and drug discovery techniquesTrack record of involvement in identifying a development candidate with a deep understanding of hit and lead generation, structure-based drug design and lead optimizationExperience managing scientific collaborations and CRO outsourcing activitiesStrong problem-solving skills with sound technically driven decision-making abilityEffective written and verbal communication skills and interpersonal skillsAn innovative team-player and leader with capacity to be effective in our dynamic and fast-paced company environmentPreferred Skills, Experience and Education:Experience in leading and managing early discovery projectsExperience in oncology drug discoveryTrack record of both scientific and people leadership across multi-disciplinary drug discovery teams including evidence of successful coaching, mentorship and development of both individuals and teams in order to build long-term organizational capabilityThe expected salary range for this role is $160,000 to $200,000. An individuals position within the range may be influenced by multiple factors, including skills and experience in role, overall performance, individual impact and contributions, tenure, and market dynamics. Base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition and veteran status.Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacyrevmed.com.

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