Associate Director, Hit Discovery

4 weeks ago


Durham, United States Life Edit Therapeutics Full time
The Role:

Life Edit is seeking an experienced scientific leader with direct industry experience in therapeutic hit discovery. The selected candidate will report to the Director, Gene Editing and lead a group of scientists to perform target exploration within the Gene Editing team.

Here's What You'll Do:
  • Lead a diverse scientific team to devise gene editing strategies for targets of interest, execute editing screening campaigns, and perform hit-to-lead activities including in vitro proof-of-concept and mechanism of action studies
  • Work closely with Corporate Development to help identify novel therapeutic targets, taking into account multiple factors including technical feasibility, commercial opportunity, and business strategy
  • Collaborate with the Computational Biology, Technology Development, and Preclinical teams to deploy Life Edit's array of genome editing systems and move lead editing compositions into animal models
  • Ensure hit discovery and optimization activities meet key milestones in a timely manner
  • Critically summarize and present data internally to interdisciplinary teams and leadership, as well as externally
  • Write reports summarizing hit discovery and optimization activities suitable for inclusion in regulatory documents
Requirements:
  • Ph.D. in biology, biochemistry, molecular biology, or a related field with 10+ years of relevant experience
  • Direct experience with hit discovery and hit-to-lead activities in the pharmaceutical or biotechnology sectors, industry experience preferred
  • Experience leading a scientific team, preferably in an industry setting
  • Demonstrated ability to collaborate in a cross functional, team-oriented environment
  • Exceptional oral and written communication skills
  • Relevant technical skills for data analysis, electronic lab notebook documentation, and presentations
  • Direct experience in the gene editing field is strongly preferred
  • A broad background in a variety of areas in biology and human therapeutics is advantageous
We're committed to finding the best ways to support our teams so they can do their best work. We take care of our employees, right from the start.

Health & Wellness
  • Medical, vision, and dental insurance covered at 90%
  • Low deductible, no co-insurance and no copays for mental health visits (for in-network care)
  • Annual fitness reimbursement
  • Employer paid for access to wellness apps and programs like Task Human
Financial
  • Competitive compensation
  • 401(k) retirement plans with a 4% employer match and no vesting period
  • Employer-paid life insurance and short- and long-term disability insurance
  • Employer-sponsored flexible spending accounts (FSA) and dependent care account (DCA)
  • Access to a 1-on-1 financial advisor
  • Commuter reimbursement benefit
  • Monthly cell phone stipend
Time Off & Flexibility
  • Unlimited paid time off, including vacation, sick leave, family leave, personal days, and bereavement
  • 18 paid company holidays, plus an end-of-year holiday shut down
  • 12 weeks of parental leave
  • Federal Family and Medical Leave Act (FMLA) and Massachusetts Paid Family and Medical Leave (PFML), administered by Unum
Development Journey
  • Insights Discovery training for every employee to make the most of workplace relationships
  • Ongoing professional development, including manager training
  • Access to LinkedIn Leaning, a self-guided online education platform


Why join Life Edit and the ElevateBio ecosystem?

Life Edit Therapeutics is an integrated subsidiary of ElevateBio, a technology-driven cell and gene therapy company that is accelerating access to the cutting-edge technologies and expertise that can change the future of medicine. Our integrated model combines multiple R&D technology platforms - including Life Edit gene editing - and cGMP manufacturing to power the discovery and development of advanced therapeutics. Our ecosystem is designed to enhance speed, delivery, and probability of success to change patient lives.

Life Edit is an integral part of ElevateBio's ecosystem of platform technologies and is pioneering focused next-generation gene editing technologies and therapeutics. Located in Durham, NC, members of Life Edit work closely with the ElevateBio Research and Development and BaseCamp manufacturing teams in Waltham, MA. Life Edit is advancing therapeutic programs in collaboration with industry partners while building its own internal pipeline of gene editing therapies. We are looking for a unique individual who can continue to lead the cultural development of Life Edit and build on its momentum as an integral part of the ElevateBio ecosystem.

Our Mission:
To power the creation of life-transforming cell and gene therapies, at a speed the world deserves.

Our Vision:
We seek to be the world's most indispensable cell and gene therapy technology company, redefining how companies operate, how products are created and how disease is treated.

ElevateBio is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. ElevateBio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

  • Durham, United States Life Edit Therapeutics Full time

    The Role: Life Edit is seeking an experienced scientific leader with direct industry experience in therapeutic hit discovery.  The selected candidate will report to the Director, Gene Editing and lead a group of scientists to perform target exploration within the Gene Editing team.    Here’s What You’ll Do: Lead a diverse scientific team to devise...


  • Durham, United States Life Edit Therapeutics Full time

    The Role: Life Edit is seeking an experienced scientific leader with direct industry experience in therapeutic hit discovery.  The selected candidate will report to the Director, Gene Editing and lead a group of scientists to perform target exploration within the Gene Editing team.    Here’s What You’ll Do: Lead a diverse scientific team to devise...


  • Durham, United States Pairwise Full time

    Job Title: Associate Director, Trait Discovery Reporting to: Director, Trait Strategy and Testing Location: Durham, North Carolina About Pairwise: Pairwise is a mission driven AgriFoodTech company pioneering the application of CRISPR technology in food and agriculture. Founded in 2017 by leading scientists in the gene editing and biotechnology fields,...


  • Durham, United States Pairwise Full time

    Job Title:  Associate Director, Trait DiscoveryReporting to:  Director, Trait Strategy and TestingLocation: Durham, North Carolina  About Pairwise: Pairwise is a mission driven AgriFoodTech company pioneering the application of CRISPR technology in food and agriculture.Founded in 2017 by leading scientists in the gene editing and biotechnology fields,...


  • Durham, United States Charles River Laboratories Full time

    Director, In Vivo Operations Req ID #: 220808 Location: Durham, NC, US, 27709 For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your...


  • Durham, United States Charles River Laboratories Full time

    Director, In Vivo Operations Req ID #: 220808 Location: Durham, NC, US, 27709 For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your...


  • Durham, United States Charles River Laboratories Full time

    Director, In Vivo Operations Req ID #: 220808 Location: Durham, NC, US, 27709 For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your...


  • Durham, United States Charles River Laboratories Full time

    Director, In Vivo Operations Req ID #: 220808 Location: Durham, NC, US, 27709 For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your...


  • Durham, United States Charles River Laboratories Full time

    For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will...


  • Durham, United States Charles River Full time

    For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will...


  • Durham, United States Charles River Laboratories Full time

    Director, In Vivo Operations Req ID #: 220808 Location: Durham, NC, US, 27709 For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your...


  • Durham, United States Charles River Laboratories Full time

    Director, In Vivo Operations Req ID #: 220808 Location: Durham, NC, US, 27709 For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your...


  • Durham, United States Charles River Laboratories, Research Models and Services, Germany GmbH Full time

    Press Tab to Move to Skip to Content Link Select how often (in days) to receive an alert: For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether...


  • Durham, United States Cypress Creek Renewables Full time

    Join Us in Powering a Sustainable Future, One Project at a Time Cypress people are drawn to work in a purpose-driven organization. We care about future generations and are inspired by the scale we continue to achieve through our experience and attention to every single project we develop, operate, manage and own. Cypress Creek’s recognition as a leading...


  • Durham, North Carolina, United States Parexel Full time

    The Associate Director of Commercial Finance is expected to lead a team focused on activities that are of the highest value for improving Parexel's market position. In doing so, the Associate Director of Commercial Finance will serve as a partner and direct point of contact to a specific customer or set of customers as well as establish standards and...


  • Durham, United States University System Of New Hampshire Full time

    Associate Director, PACS Training Services For optimal experience, internal candidates should use their USNH username and password when applying for open positions. Operating Title Associate Director, PACS Training Services Long Classification Title Long Classification Title Associate Director, Psychological and Counseling Services Campus...


  • Durham, United States Biogen Full time

    About This Role:This critical position provides operational oversight of the Manufacturing Technical Operations (MTO) function for the Small Scale Manufacturing (SSM) and Flexible Volume Manufacturing (FVM) factories at out RTP Bio Site. This positio Technical, Operations, Manufacturing, Director, Associate, Operation, Technology


  • Durham, United States Fidelity Investments Full time

    Job Description: Position Description: Designs, develops, and modifies complex and major software systems using scientific analysis, mathematical models, and tools and technologies -- Snowflake, Oracle, SQL and PL/SQL, Apache, NiFi, and Kafka. Plans and coordinates project schedules and assignments for multiple projects. Identifies and acquires talent needs,...


  • Durham, United States Fidelity Investments Full time

    Job Description: Position Description: Designs, develops, and modifies complex and major software systems using scientific analysis, mathematical models, and tools and technologiesSnowflake, Oracle, SQL and PL/SQL, Apache, NiFi, and Kafka. Plans and coordinates project schedules and assignments for multiple projects. Identifies and acquires talent needs,...


  • Durham, United States Fidelity Investments Full time

    Job Description: Position Description : Designs, develops, and modifies complex and major software systems using scientific analysis, mathematical models, and tools and technologiesSnowflake, Oracle, SQL and PL/SQL, Apache, NiFi, and Kafka. Plans and coordinates project schedules and assignments for multiple projects. Identifies and acquires talent needs,...