Head of ADME

Cyprotex, an Evotec company, specializes in ADME-Tox and Biosciences including both in vitro (laboratory experiments) and in silico (computer modelling) approaches. Cyprotex was founded in 1999. The Company serves the Pharmaceutical and Biotech, Cosmetics/Personal Care and Chemicals Industries as well as academia and not-for-profit organizations. Over 1700 organizations trust Cyprotex for their ADME-Tox and Bioscience research needs. We are seeking an enthusiastic DMPK scientist to lead our US ADME Sciences function. Responsible for managing the scientists and resources that provide our high-throughput and custom ADME services as well as leadership to our Biotransformation and Bioanalysis functions. Leading the development of new methods and technologies and implementing process improvements, this role is pivotal in maintaining Cyprotex’ reputation in the ADME field. The individual will work closely with the Director of Scientific Operations and the other Heads of functions to be part of the core operational management structure responsible for day-to-day decision making and improvements across Cyprotex in the US. This role is based in Framingham, Massachusetts. Job Responsibilities ·

To lead the US ADME sciences function and manage the resources, both personnel and instrumentation, within that group. To drive-forward the techniques used at Cyprotex and to ensure that quality and efficiency are always maintained. To ensure that a wide-range of chemistries can be assessed including compounds and ingredients from chemical and personal care industries as well as typical small molecule pharmaceutical compounds. ·

To investigate new instrumentation and assess suitability for integration into Cyprotex systems. To then work closely with the Cyprotex Information Systems Team to integrate new technology and procedures into the Cyprotex LIMS. ·

To work closely with the Director of Scientific Operations and other Heads of Functions to help oversee the core operational activities of Cyprotex in the US. ·

To take a proactive role in developing the ADME Sciences function and provide advice to the Cyprotex Leadership Team, where appropriate. To raise the scientific profile of the company by actively pursuing opportunities to present Cyprotex externally. ·

To identify areas within the ADME Sciences function for improvement, promote efficiency, and to modify approaches to sample analysis as the customer landscape changes. ·

To support the Business Development team with preparing proposals for clients and developing client relationships by occasional site visits and teleconferences. To contribute to plans for new projects including pricing, implementation and sourcing of CapEx. ·

To oversee training and development of staff within ADME Sciences and provide scientific direction and line management to staff. ·

To directly manage some client studies where the focus of the study is analytical and/or non-standard analytical methods are used. ·

To work closely with UK-based colleagues and colleagues within the wider Evotec Group to maintain a consistent approach to ADME Sciences. Qualifications PhD trained in ADME sciences from an internationally recognized academic program with 10 + years of experience Extensive hands-on experience of operating and trouble-shooting ADME assays Deep experience with LC-MS/MS instrumentation across a range of manufacturers and software applications. Experience with high-resolution mass spectrometry and high-throughput LC techniques desirable. Exposure to any or both of the following would also be advantageous: Analysis of biotherapeutics. Metabolite profiling and identification Line management and development and coaching of staff. Experience in pharmaceutical, biotech or contract research organizations within roles such as analytical method development and/or high-throughput analytics in support of ADME studies, would be preferable.

Knowledge, Skills and Abilities Excellent interpersonal skills with laboratory staff, project managers, clients and senior managers Approachable and builds constructive and effective long-lasting relationships Presents convincingly and confidently in a variety of formal and informal settings Communicates proactively and regularly, keeping all internal and external stakeholders updated Inspires and enthuses others Acts as role model by being open, honest and cooperative Ability to effectively time manage and prioritize tasks Identifies opportunities for improvement Evotec is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, gender, age, disability, genetic information, gender expression, gender identity, national origin, religion, sexual orientation, or veteran status. Evotec (US) Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, gender, age, disability, genetic information, gender expression, gender identity, national origin, religion, sexual orientation, or veteran status. About Us

Evotec is a life science company with a unique business model that delivers on its mission to discover and develop highly effective therapeutics and make them available to the patients. The Company’s multimodality platform comprises a unique combination of innovative technologies, data and science for the discovery, development, and production of first-in-class and best-in-class pharmaceutical products. Evotec leverages this “Data-driven R&D Autobahn to Cures” for proprietary projects and within a network of partners including all Top 20 Pharma and over 800 biotechnology companies, academic institutions, as well as other healthcare stakeholders. Evotec has strategic activities in a broad range of currently underserved therapeutic areas, including e.g. neurology, oncology, as well as metabolic and infectious diseases. Within these areas of expertise, Evotec aims to create the world-leading co-owned pipeline for innovative therapeutics and has to-date established a portfolio of more than 200 proprietary and co-owned R&D projects from early discovery to clinical development. Evotec operates globally with more than 5,000 highly qualified people. The Company’s 17 sites offer highly synergistic technologies and services and operate as complementary clusters of excellence. For additional information please go to www.evotec.com

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