Staff Research Associate I

3 weeks ago

San Francisco, United States University of California San Francisco Full time

The Brain Tumor Center at UCSF focuses on developing new treatments for patients with malignancies of the central nervous system by
- (1) studying the mechanisms through which brain tumors develop and become resistant to treatments and
- (2) identifying novel therapeutic targets using molecular biology, CRISPR genome and epigenome editing, biochemistry, mouse genetics, bioinformatics, pharmacology, and multidisciplinary collaborations.- Under direct supervision and guidance, the Staff Research Associate will play an instrumental role in developing and deploying genetic and epigenetic editing technologies for treating malignant gliomas, working side-by-side with physician-scientist investigator Dr. John Liu (MD/PhD Assistant Professor) and under supervision of Dr. Mitchel Berger, Director of the UCSF Brain Tumor Center.
- This project specifically involves close collaboration across the labs of the UCSF Brain Tumor Center as well as the UCSF Preclinical Therapeutics Core. The employee will learn and utilize a variety of research techniques and have the opportunity to be a co-author on publications as well as present at international conferences.
- Under direct supervision and guidance, the job responsibilities and opportunities include but are not limited to:

- Molecular biology including molecular cloning, PCR, DNA/RNA/Protein analysis, DNA methylation epigenetic analysis including bisulfite sequencing
- Culturing human and mouse cancer cell lines, primary brain tumor cultures, and organoids
- Flow cytometry, immunofluorescence, and confocal microscopy analysis
- Performing gene knockdown and epigenetic editing using engineered CRISPR/Cas9 technologies, including genome-wide CRISPR screens
- Assisting with mouse colony management, including breeding, weaning, tagging, and PCR genotyping
- Assisting with intracranial xenograft studies and pharmacologic experiments in mice
- Dissection and dissociation of tumor xenografts for single cell RNA-seq and multi-omics analysis
- Assisting with lab maintenance duties including acquisition of materials and documentation

Prior familiarity with these techniques is a plus but not required, and a willingness to learn new techniques is expected. In addition, the successful applicant will receive direct mentorship to ensure that specific laboratory responsibilities are tailored and directed toward future career objectives, such as the pursuit of a MD, biomedical PhD, or MD/PhD.For roles covered by a bargaining unit agreement, there will be specific rules about where a new hire would be placed on the range.

**Department Description**
- The Department of Neurosurgery at UCSF is one of the most pre-emanate neurosurgical departments in the country for clinical care, training and research. The department is number one academic research publication productivity and recently named as one of the top Neurosurgery Training Programs in the country. The Department is also ranked 4th in the nation for Neurosurgery & Neurology and is the number one Neurosurgery Department on the west coast (US News & World Report). Central administration at the Parnassus Heights location is responsible for directing all administrative functions of the department. The department’s Spine Group Team is currently located at UCSF Parnassus Campus.

**Required Qualifications**
- BA/BS in a related science and knowledge of, or experience with, the basic techniques or methods required by the position; and/or an equivalent combination of education and experience;
- Strong degree of self-motivation, eagerness to learn and think critically, and enthusiasm for science and/or medicine
- Attention to detail and problem solving ability
- Demonstrated reliability and integrity
- Strong organizational, communication, and documentation skills.
- Initiative to work well as part of a team and also independently.

**Preferred Qualifications**
- Basic knowledge and understanding of cancer biology
- Effective use of laboratory instruments and their maintenance; knowledge of biomedical and biotechnological techniques and methodologies
- Working knowledge in tissue culture and basic molecular/cell biology
- Knowledge and experience with CRISPR/Cas9 techniques

**About UCSF**
- The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. It is the only campus in the 10-campus UC system dedicated exclusively to the health sciences. We bring together the world’s leading experts in nearly every area of health. We are home to five Nobel laureates who have advanced the understanding of cancer, neurodegenerative diseases, aging and stem cells.

**Pride Values**
- In addition to our PRIDE values, UCSF is committed to equity - both in how we deliver care as well as our workforce. We are committed to building a broadly diverse community, nur

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