Associate Director, Bioinformatics Upstream R&d San

4 weeks ago

San Carlos, United States Nautilus Bio Full time

Location
- San Carlos, Seattle, San Diego

Type
- Full time

Department
- Software & Bioinformatics

Compensation

$164K - $221K - Offers Equity - Offers Bonus
- The hiring pay range for this position is based on skills, education and experience relevant to the role; title may be assessed one level lower or higher, accordingly. Other components of total compensation include a competitive options grant at the time of hire (with potential for additional grants) and annual bonus.
- Benefits include medical, vision, and dental insurance, group and supplemental life insurance, 401k retirement plan, responsible (unlimited) paid time off, parental leave, and more.

At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome - one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing hard scientific problems with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines.

This position will report to the Associate Director, Bioinformatics and can be in San Carlos, CA; Seattle, WA; and we are open to consider San Diego, CA.

**Responsibilities**- Lead the bioinformatics team responsible for supporting all our upstream R&D efforts, such as probe development and qualification, including determining research priorities and approaches for the team.-
- Assess in silico approaches to affinity reagent design and optimization, both internally and externally.-
- Contribute to company-wide strategic planning by leveraging existing data and assumptions grounded in biology to forecast and predict outcomes in hypothetical scenarios.-
- Assist wet-lab scientists with experimental design, data analysis, and interpretation of results in the domains of assay development, selection of antibodies and other affinity reagents, and evaluation of binding kinetics.-
- Implement custom machine learning approaches to improve throughput and success rate of the overall probe development pipeline.Serve as the technical representative for the Upstream Bioinformatics team company wide.-
- Maintain existing and establish new external collaborations.**Requirements**:
- A PhD degree in Bioinformatics, Computational Biology, or similar field.5+ years of experience in a bioinformatics leadership role.-
- Excellent track record of leading complex bioinformatics projects throughout all stages, from inception to deployment.-
- Proven ability to guide experimental design, model biological interactions in silico, and generate inferences from data using customized modeling approaches.Experience building automated end-to-end data processing pipelines that deliver actionable conclusions to scientists.-
- Fluency in a variety of programming languages, frameworks, and tools, especially Python.-
- Must have experience with building novel tools and working with raw data.-
- Experience with modeling software such as Rosetta or Schrodinger preferred.-
- Competency with SQL and AWS.-
- Strong organization and communication skills, with the ability to lead others both directly and through collaboration.Ability to have fun when building complex systems while working side-by-side with experts from a variety of disciplines.-
- Self-motivated, driving projects forward to meet deadlines.**Nautilus Team Culture**- We are curious go-getters: this is a team of life-long learners who aren’t afraid to tackle the big challenges while continuously pushing ourselves forward.-
- We are detail oriented: we do great science by working smart and with diligence, and by learning from our mistakes.-
- We are easy to work with: we want our workplace to be one where everyone can share their perspective and be treated with respect and kindness.#LI-ONSITE

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