Biologist

4 weeks ago

Gaithersburg, United States GAP Solutions, Inc. Full time

Provide services as a Biologist in support of the overall functions of the Vaccine Production Program (VPP), Vaccine Research Center (VRC) within the National Institute of Allergy and Infectious Diseases (NIAID).

**Duties and Responsibilities**:

- Purify research-phase recombinant proteins, virus vaccines and/or virus-like particles in support of other groups or external collaborators.
- Perform _In vitro _Transcription (IVT) and mRNA purification at multiple scales.
- Work to prepare necessary materials (buffers, packed columns, etc.) in support of downstream process activities.
- Support technology transfer of processes to Lab’s Pilot Plant for manufacture of clinical product through document generation and on-site support.
- Write and review technical protocols and reports.
- Analyze and compile data, present at various group/department meetings.
- Collaboratively build and execute high-throughput purification processes on TECAN, Sartorius, and other automated process development platforms.
- Support process development activities by generating data from a wide variety of traditional and high-throughput analytical modalities such as SDS-PAGE, and UV/Vis/Fluorimetry assays.
- Design, test, and implement data transformation, modeling, and analysis pipelines, to include development of custom programs written in Python, Matlab, or Perl, etc.
- Assist the development, and implementation of digital informatics systems for the downstream purification department.

**Basic Qualifications**:

- Bachelor’s degree in Bioengineering, Chemical Engineering, Biochemistry, or a related discipline.
- Minimum of two to five (2-5) years of experience in recombinant protein, pDNA, and mRNA purification development for GMP clinical-phase products.
- Experience with In vitro Transcription (IVT) and mRNA purification.
- Experience using high-throughput bioprocessing systems such as TECAN.
- Demonstrated knowledge of maintaining accurate and detailed records.
- Familiarity with computer software including word processing and data evaluation.

**Minimum Qualifications**:

- Ability to communicate effectively, orally and in writing, with non-technical and technical staff.
- Must be a team player who can effectively work with members from cross-functional departments.
- Detail-oriented and possess strong organizational skills with the ability to prioritize multiple tasks and projects
- This job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required by this position.

To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

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