Scientist, Cmc Radiochemistry

4 weeks ago

Watertown, United States Mariana Oncology Full time

**Description**:
Mariana Oncology is focused on an extremely exciting field of oncology of precision radiopharmaceuticals to treat unmet need in solid tumors. We are at the vanguard in developing best-in-class alpha
- and beta-emitting radioligands that target cancer, while mitigating destruction to healthy tissue and cells. We have built a fully-integrated, leading radiopharmaceutical platform, bringing together novel target biology insights, innovative multimodal ligand discovery, and enabling translational infrastructure.

We are actively seeking talented individuals to join us who are looking to make an impact in science and in the lives of cancer patients. Our team is a collective group who is excited about being part of building a successful biotech company, and in honing their knowledge and experience to enhance their careers.

We have just moved into beautiful new offices in Arsenal Yards in Watertown, MA. In our new home we now have our office space, research labs, and GMP manufacturing suite all in one place.

We are seeking an experienced **Scientist, CMC Radiochemistry** to join Mariana’s **CMC **organization, advancing personalized medicine and radiopharmaceuticals.

***Illustrative Breadth of Responsibilities**:

- Implement and perform new and/or routine radiochemistry procedures and protocols under the direction of the CMC team
- Investigate, analyze, and reach preliminary scientific conclusions related to research planning
- Ensure data results are compiled, analyzed, and presented properly
- Analyze, develop, interpret, and maintain clear documentation of scientific results
- Prepare scientific reports for internal reporting purposes
- Perform independent research and laboratory techniques and participate in experimental research planning
- Opportunity to engage in early drug product formulation feasibility process development and analytical methodologies
- Opportunity to learn radiolabeling/ coordination chemistry process, analytical development and troubleshooting with a broad range of radioisotopes, including but not limited to: Lu-177, Ac-225, Zr-89, Cu-64, In-111, Ga-68 and Pb-212
- Participate in the development and process validation of radiopharmaceutical production procedures for use in preclinical and clinical studies
- Participate and support CMC process and analytical development, method validation, and reporting activities
- Support team communications in disseminating the results, which may come in the form of writing reports, presenting at internal meetings
- Contribute to the organization, safety, and maintenance of the laboratory

**Requirements/Skills**:

- A BS degree in Chemistry, Radiochemistry, or related discipline with +2 years of Biotech, Pharmaceutical, and/or PET industry experience in relevant biologics and peptides metal chelates chemistry development. Alternatively, a M.S. or Ph.D. degree in Chemistry with direct and relevant industry experience
- Knowledge of GMP is a plus
- Radiopharmaceutical drug substance and drug product development experience and quality control is a plus
- Analytical chemistry and knowledgeable in HPLC separation science
- Working with radiopharmaceuticals, with a good understanding of the radiation safety regulations and guidelines, is preferred
- Proven ability to adhere to good documentation standards and maintain detailed records of all work performed
- Excellent verbal and written communication skills

**Mariana Oncology’s Principles**
- **Building a Legacy**:

- **Execution Excellence**:

- **Courage of our Convictions**

**What Success Looks Like at Mariana Oncology**

**Entrepreneurial Mindset**:
We are all working in an exciting and new space of life sciences, and the only way we’re going to be successful is by working together. We will be tested in ways that require us to improve our skills, learn from our mistakes, and take continuous action on ideas. By sharing our work, explaining our processes, and highlighting the takeaways we derive from our experiments, we will all learn and grow as a team.

**Believing the Glass is Half-Full and Having Self-Confidence**:
We need you to bring all your courage and willingness to advocate positions based on doing the right things; identify and focus on the positives and potential of every business and scientific opportunity. There will be times when we’re in uncharted territory and working without a lot of direction. When things get challenging, we must look out for each other. Sometimes, even something as simple as saying, “thank you” or “great work” can go a long way.

**Leadership**:
We’re looking for role models who can think and work across the enterprise and inspire others to perform at their very best. If you are passionate about improving the lives of people suffering from cancer, empowering others, and being a positive force for change, the join us. Together we can defeat cancer’s toughest tumors

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