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Scientist
1 month ago
Our global team operates out of two leading life science clusters, Watertown, MA and Medicon Village in Lund, Sweden.
**Position Overview**:
The Scientist will be a key member of Acrivon Therapeutics’ Drug Discovery Team and will be supporting its _in vitro_ pharmacology, mechanism-of-action studies, and biomarker identification efforts. This position will be based in Watertown, MA.
**Duties and Responsibilities**:
- Independently design and perform mid to high-throughput plate-based cellular assays to profile compounds, understand their mechanism of action, and/or identify relevant biomarkers.
- Perform cell line engineering, assay development, and large cell line panel screens.
- Analyze, interpret, and summarize data for team meeting presentations and document experiments in electronic lab notebook.
- Manage CROs for outsourced work.
- Work collaboratively in a team-oriented, matrixed, cross-functional context.
**Requirements and Qualifications**:
- BS in Biological Sciences or a related discipline with 6+ years industry experience; or MS with 4+ years industry experience; or Ph.D. with 2+ years experience.
- Extensive mammalian cell culture experience is required.
- Demonstrated hands-on experience with mid to high-throughput plate-based assays including target engagement, cell viability, and cell death assays (e.g., ADP-Glo, NanoBRET, AlphaLISA, CellTiter-Glo, CellTox-Green, real-time live cell imaging) is preferred.
- Experience in cell line engineering using CRISPR and/or lentiviral methods + experience generating drug-resistant lines is preferred.
- Familiarity with liquid handling and automation is desirable.
- Flow cytometry and/or high content imaging experience is a plus.
- CRO management experience is a plus.
- Strong work ethic and great attention to detail.
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