Head of Proteomics

1 week ago

San Diego, United States Sapient Full time

Sapient is a fast-growing early-stage biotech company headquartered in San Diego, CA. Our focus is on delivering multi-omics services to accelerate drug development and transform personalized medicine. Combining state-of-the-art mass spectrometry technology with advanced biocomputational services and multifaceted human health data, we enable biomarker discovery at unprecedented speed and scale to provide a deeper understanding of human biology and effectively align biological targets, patients, and drug therapies. We are a highly collaborative team of passionate scientists, clinicians, and engineers with expertise in various disciplines, committed to making innovations with scientific rigor. Ultimately, our platform technology enhances the precision and efficacy of treatments, touching and enhancing countless lives.

We are seeking a **Head of Proteomics** to join our dynamic and growing company.

**Responsibilities**:

- Drive analytical innovation and biological discovery in a state-of-the-art proteomics lab
with a team.
- Manage proteomics department including logístical planning of resources for client
projects as well as R&D efforts, personnel management and recruiting, and advocating
for additional resources and budget.
- Work closely with the data science team to provide insights into complex multi-omic
data as well as interact with the commercial team to curate new product offerings and
literature such as case studies, white sheets and research publications.
- Collaborate with scientists and clinicians to investigate scientific and medical problems
with rigorous analysis and critical thinking.
- Ensure data quality through implementation of data monitoring, QC metrics,
standardized operating procedures, and formal staff training.
- Able to perform and communicate within a collaborative environment with an emphasis
on data quality, integrity, and adherence to project deadlines.
- Provide critical input on and communication of proteomics study results and present
scientific data.

**Requirements**:

- PhD in Chemistry, chemical engineering, bioengineering, biochemistry, biology, or related scientific field
- A minimum of 7 years, post PhD, of professional experience working in proteomics with a focus on, but not limited to,
mass-spectrometry-based methods
- Extensive experience with development and implementation
of sample preparation workflows for label-free bottom-up
proteomics from a wide array of biomatrices.
- Extensive experience with LC-MS method development,
implementation, validation, QC, and troubleshooting for
proteomic sample analysis using DIA and DDA data
collection workflows, especially with Bruker timsTOF
instruments.
- Experience with development and validation of targeted
protein assays, ideally within a regulated framework is
desired.
- Experience with leading teams and project management.
- Deep understanding of how to utilize lab automation and
leverage LIMS/ELN systems in a regulated environment,
while using discretion and scientific judgement.
- Strong oral and written communication skills with the ability
to serve as proteomics SME in client interactions,
collaborate with peers, mentor others, and create business
impact through meaningful analysis of data.

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