Research Assistant Ii Genomic Medicine
4 weeks ago
The Johnston Laboratory is an interdisciplinary and highly collaborative team of microbiologists, synthetic biologists, bioinformaticians and engineers. The long-term goal of our research is to gain a comprehensive understanding of the capabilities of microbes/microbial communities within tumors, elucidate the underlying mechanisms driving their behavior, and utilize this knowledge to engineer innovative therapeutics and advanced microbe-based technologies for cancer prevention and treatment. To achieve this, we employ cutting-edge bacterial omics techniques (including pangenomics, pan-epigenomics, transcriptomics, and metabolomics) to generate hypotheses centered on understanding how specific microbes migrate to, colonize, and persist within human tumors. We then utilize synthetic microbiology principles to develop genetic systems for these tumor-associated microbes, allowing us to experimentally test and refine our hypotheses using in-vitro and pre-clinical models of disease. Moreover, using knowledge gained, we aim to harness the innate abilities of microbes to access recalcitrant areas of the tumor microenvironment and engineer them as effective delivery vehicles for therapeutic payloads (bugs as drugs).
Key Functions
- Aerobic and anaerobic bacterial culture and stock maintenance, genetic engineering/transformation of the such strains.
- Adhere to standard operating procedures (SOPs) for isolation and analysis of DNA and RNA from microbial specimens, including PCR, quantitative PCR, RT-PCR, and sequencing.
- Assist in the design of experiments.
- Conduct literature reviews to assist in determining most suitable methods to be used in research.
- Conduct diligent record-keeping and reporting
- Presenting findings at internal (Johnston Lab) meetings
- Assist in the development and implementation of standar operating procedures.
- Maintains and supports shared tools and databases.
- Documents experimental results and maintains clear record of all experimental work performed in laboratory notebooks and completes all documentation with clear and accurate language according to the standard operating procedures.
- Assists in general laboratory operation, ensures the laboratory is prepared for experiments, perform related laboratory maintenance such as maintaining and cleaning equipment.
- Assist with monitoring and stocking supplies, preparation of stock solutions and other reagents.
- Orders supplies for projects and monitors and anticipate laboratory needs in terms of equipment and supplies.
- Participate in laboratory meetings and presents progress reports.
- Studies literature and confers with supervisor regarding new procedures.
- General lab maintenance including but not limited to ordering or organizing laboratory supplies and ensuring maintenance of equipment.
- Perform additional work as required.
Core Competencies
Analytical Thinking - Gather relevant information systematically; break down problems into simple components; make sound decisions.
Innovative Thinking - Approach problems with curiosity and open-mindedness; offer new ideas, solutions and/or options.
Team with Others - Initiate, develop, and manage relationships and networks; encourage collaboration and input from all team members; value the contributions of all team members; balance individual and team goals.
Technical/Functional Expertise - Demonstrate technical proficiency required to do the job; possess up-to-date knowledge in the profession; provide technical expertise to others.
- Highly-motivated individual interested in a career in biological research or medicine, with a keen interest in genetic engineering of microbes
- Technically meticulous when conducting experiments
- Highly organized in record-keeping
- Independent, intellectually passionate and able to display scientific initiative
- Excellent teamwork, time management and organizational skills
- Ability to work independently in a dynamic and results-oriented environment
- Ability to meet deadlines and multitask efficiently is a must
- Basic molecular biology and microbiology techniques, such as aseptic technique, bacterial isolation and culture, strain library maintenance, PCR, DNA/RNA/protein extraction, cloning, recombineering, etc. are stringently required.
A working knowledge and previous wet-lab experience with transformation of non-model bacterial organisms (optimization of competent cell preparation/heat shock/electroporation), in addition to standard coli transformations, is highly desirable and preferred.
Experience in the design and use of reagents for DNA cloning and genome engineering with shuttle vectors, suicide-vectors, CRISPR/Cas9 and transposon mutagenesis technologies also desirable.
Working knowledge and experience in anaerobic culture (anaerobic chamber use) will be beneficial to the role.
is an interdisciplinary and highly collaborative team of microbiologists, synthetic biologists, bioinformaticians and engineers. The long-term goal of our res
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