Postdoctoral Scientist

CrossLife Technologies is a San Diego based **Point of Care Diagnostics** company who develop and commercialize novel diagnostics based on innovative nucleic acid technologies for many diseases. We are seeking a Postdoctoral Scientist - Protein Structure (full-time) position.

**Key Responsibilities**:

- Perform computational molecular design and modeling to inform and accelerate

the design and development of high quality, differentiated therapeutics
- Lead and support our internal, early portfolio of RNA, protein, gene and cancer

therapy programs.
- Contribute and participate in internal and external presentations, peer-reviewed

manuscripts and conference proceedings.

**Qualification**:

- PhD in Biomedical Engineering, Biochemistry, Computational Biology, Computer

Science, Structural Biology, Biophysics, Material Science, or other related

quantitative field is required.
- Experience in applied AI/ML or molecular modeling in drug discovery and

development including protein library design and selection is required.
- Experience with structural modeling of Protein-small molecules, protein-protein,

protein-DNA and protein-RNA interactions, protein and RNA folding is preferred.

methods (LMs, diffusion models, etc) for the design and optimization of RNA or

proteins is preferred.
- Experience using one of the following: Schrodinger, FoldX, Rosetta, Discovery

Studio, MOE, GROMACS, NAMD, or other molecular dynamics simulation

software, is required.
- Demonstrated ability to evaluate and deploy computational tools, algorithms and

platforms using internal and external datasets and benchmarks is required.
- Experience in the evaluation, design, development and deployment of molecular

models, algorithms and platforms across the enterprise in a cloud computing

environment (AWS, Azure, Google) is preferred.
- Hands-on experience in high performance scientific computing, software

engineering, deployment and scaling to the enterprise is required.
- Self-motivated individual, with experience working independently and as part of a

larger interdisciplinary team is required.
- Excellent communication, reporting and presentation skills and desire for

continuous learning and the ability to identify, evaluate and implement emerging

algorithms and models are required.
- Has a working knowledge of Biosimilar development ideally and must have an in
- depth knowledge of analytical techniques used for antibody/protein analysis
- Characterization of therapeutic proteins (recombinant proteins expressed in

eukaryotic and prokaryotic cells)
- Independent and thorough work on scientific projects and optimization of

existing methods (independent literature research, planning and execution of

experiments, evaluation and documentation of results)

**Benefits**:

- Dental insurance
- Health insurance
- Paid time off
- Retirement plan
- Vision insurance

Compensation package:

- Bonus opportunities

Experience level:

- 5 years

Schedule:

- Monday to Friday

**Education**:

- Doctorate (preferred)

Ability to Relocate:

- Carlsbad, CA 92008: Relocate before starting work (required)

Work Location: In person