Oligo Discovery Chemistry Principal Scientist

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people's lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients' needs and have the highest probability of success. We're uniting science, technology, and talent to get ahead of disease together. The successful candidate will help to establish pre-clinical capabilities within GSK's new oligo synthesis lab. Areas of focus are producing small molecules, lipids, and linkers for ASOs, siRNA, SSO, and RNA editors conjugates, discovery chemistry, and method development. Your expertise will enable us to solve complex chemical challenges, pushing the boundaries of what's possible in oligonucleotide therapeutics. Perform hands-on work, establish small molecule, lipid, linker, and other synthetic workflows including designing structure activity relationship studies, implementing synthetic routes, and drafting SOPs in support of next generation chemistry and method development. Serve as the small molecule and lipid SME for the team, representing conjugates in various cross matrix meetings. Develop and maintain SOPs for synthesis, processing, and purification to ensure high-quality, reproducible results. Work with the oligo analytical and conjugate chemistry teams to ensure accountability and excellence in small molecule and lipid conjugate synthesis. We are seeking professionals with the following required skills and qualifications to help us achieve our goals: ~ PhD with 3+ years' experience in chemistry, oligonucleotide synthesis, or chemical biology or related fields. ~2+ years of industry experience in modern synthetic chemistry methods, particularly with small molecules, lipids, linkers, amidite synthesis, purification, and analysis. ~ Experience with HPLC purification techniques such as reverse phase, size exclusion, ionic chromatography potentially using Agilent, Waters, or Cytiva ÄKTA Avant and Pure purification systems, and LC/MS analytics. ~ Experience in lipid, PEG-lipid, sterol, dinucleotide, and amidite synthetic chemistry, and biological familiarity of RNA therapeutics (e.g. Prior experience with scientific and professional mentorship and project leadership. Prior experience with oligonucleotide synthesis and nucleoside chemistry is desirable but not required. This role is fulltime on-site at our Cambridge MA offices. We look for practical problem solvers who communicate clearly and act with scientific rigour. We look forward to learning how your skills and experience can help us get ahead of disease together. #Analytical Chemistry, Data Analysis, Design Thinking, Drug Design, Drug Discovery Process, Medicinal Chemistry, Synthetic Organic Chemistry
• The US salary ranges take into account a number of factors including work location within the US market, the candidate's skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. HIV; Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people. If you require an accommodation or other assistance to apply for a job at GSK, please contact the appropriate Recruitment Staff by emailing us at
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